INTRODUCTION Male Sickle cell disease (SCD) patients often have moderate to severe hypogonadism resulting in abnormal seminal fluid parameters due to testicular dysfunction. Hydroxyurea (HU), the only drug found to be effective in preventing morbidity and mortality in sickle cell disease patients has been found to further aggravate the testicular dysfunction. MATERIAL AND METHODS This was a p...

OBJECTIVE To investigate the impact of subinguinal microsurgical varicocelectomy on semen parameters and pregnancy outcomes in couples with male factor subfertility. DESIGN Case series. SETTING Male Infertility Clinic in an academic institution in Hong Kong. PATIENTS The clinical records of 42 consecutive subfertile male patients who had subinguinal microsurgical varicocelectomy (from Jan...

Mean plasma testosterone levels (+/- S.D.), using Sephadex LH-20 and competitive protein binding, were 629 +/- 160 ng/100 ml for a group of 27 normal adult men, 650 +/- 205 ng/100 ml for 27 impotent men with normal secondary sex characteristics, 644 +/- 178 ng/100 ml for 20 men with oligospermia, and 563 +/- 125 ng/100 ml for 16 azoospermic men. None of these values differ significantly. For 21...

OBJECTIVE The most frequent known genetic causes of severe oligospermia (< 5 million sperm/ml) or azoospermia in men are Klinefelter's syndrome (KS), and deletions in the Y chromosome long arm (Yq). We aimed to compare the function of the pituitary-testicular axis in patients with severe oligospermia or azoospermia, idiopathic or associated with Y chromosome deletions or Klinefelter's syndrome ...

BACKGROUND To determine the differences in sperm quality and results of intracytoplasmic sperm injection (ICSI) cycles between three groups of male factor infertile couples: oligozoospermic, obstructive azoospermic and non-obstructive azoospermic. MATERIALS AND METHODS In this prospective cohort study, 628 male factor infertile couples who underwent ICSI cycles from April 2004 to March 2006 w...

BACKGROUND Global ubiquitination in human semen has been found to negatively correlate with standard semen parameters, indicating that ubiquitination can be considered a marker of poor semen quality. However, the inclusion of all semen components in the analysis may be misleading on the biological significance of ubiquitination of sperm cells. We have recently demonstrated the variable presence...

is devoted to factors which might have a deleterious effect upon apparently normal spermatozoa, with chapters on spermigration in the female secretions, special technics in spermatozoal study, the longevity of spermatozoa in vivo, the effect of temperature on the survival of spermatozoa in vitro, and abnormalities in the female which inhibit impregnation. There is a discussion of artificial ins...

Here we investigated the effects of Tribulus terrestris L. on sperm morphology and acrosome reaction in subjects with oligoasthenoteratozoospermia. A double-blind placebo-controlled trial was performed with 30 primary and secondary infertile men. Half received oral Tribulus (Libilov, 500mg dose) three times per day for 60 days, and the rest were given sugar pills. The ejaculate volume, sperm co...