OBJECTIVES/HYPOTHESIS The aim of this study was to evaluate the effects of olfactory training (OT) on olfactory function in patients with persistent postinfectious olfactory dysfunction (PIOD). STUDY DESIGN Randomized, single-blind, controlled, multicenter crossover study. METHODS Twelve tertiary university medical centers participated. Investigations were performed at three visits (baselin...

Paolo Boscolo-Rizzo, MD; Daniele Borsetto, Cristoforo Fabbris, Giacomo Spinato, Frezza, Anna Menegaldo, Francesca Mularoni, Piergiorgio Gaudioso, Diego Cazzador, Silvia Marciani, Samuele Frasconi, Maria Ferraro, Cecilia Berro, Chiara Varago, Piero Nicolai, Giancarlo Tirelli, Cristina Da Mosto, Rupert Obholzer, MA, MBBS; Roberto Rigoli, Jerry Polesel, ScD; Claire Hopkins, MBBS

INTRODUCTION In the general population, we can find 2-3% of lifelong olfactory disorders (from hyposmia to anosmia). Two of the most frequent aetiologies are the common cold and flu. The aim of this study was to show the degree of long-term olfactory dysfunction caused by a cold or flu. METHODS This study was based on 240 patients, with olfactory loss caused only by flu or a cold. We excluded...

BACKGROUND Despite the significant health impact of olfactory loss in chronic rhinosinusitis (CRS), the underlying pathophysiology is incompletely understood. A transgenic mouse model of olfactory inflammation induced by tumor necrosis factor-alpha (TNF-α) has provided new insights into the cellular and molecular basis of inflammatory olfactory loss. Here, we utilize systemic corticosteroids to...

OBJECTIVES Several prognostic factors influencing the recovery from olfactory dysfunction have been described. The aim of this study was to investigate whether olfactory bulb volume could be used as a new predictor of olfactory recovery in postinfectious and posttraumatic olfactory loss. STUDY DESIGN Cohort study; Level of evidence, 4. Setting Tertiary university clinic, department of otolary...

The amyloid beta peptide aggregates into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the temporal relationship between plaque formation and neuronal dysfunction is poorly understood. Here we demonstrate that the connectivity of the peripheral olfactory neural circuit is perturbed in mice overexpressing human APPsw (Swedish mutation) before the onset of plaques. Expressi...