This review summarizes recent data which implicate cell membrane receptors and their associated signal transduction pathways as molecular targets of tobacco-related lung carcinogenesis as well as therapy of such cancers. It is shown that the two nitrosamines N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bind to nicotinic cholinergic receptors in hamster lung. Binding ...

The metabolic activation of several chemical classes of procarcinogens is being studied in cultured human bronchi. Previous studies have shown that carcinogenic polynuclear aromatic hydrocarbons are metabolically activated by the bronchial epithelium. In the study reported here, dimethylnitrosamine and 1,2-dimethylhydrazine were also found to bind to both cellular DNA and protein. Bronchial DNA...

Research focused on preparing new type curing pigment, which called Nitroso-hemoglobin prepared by use of by-products (beef blood), and its application prospect substitutes of nitrite, because of its a poisonous reagent, and can produce carcinogenic nitrosamine after reacting with amine and lead to carcinogenicity, nitrosamines toxicity in meet's product, and this project defined the developmen...

The role of urine as a tumor-enhancing agent in urinary bladder carcinogenesis was investigated by using the heterotopically transplanted rat urinary bladder. Bladders removed from rats initiated with the carcinogen /V-butyl-/V-(4-hydroxybutyl)nitrosamine in drinking water for 4 or 10 weeks were heterotransplanted to syngeneic rats. Those heterotopically transplanted bladders receiving repeated...

The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. To further investigate this hypothesis, we submitted Ptc(+/-) heterozygous mutant mice and their wild-type l...

Data from a randomized controlled trial and systematic review support the claim that switching from tobacco cigarettes to electronic cigarettes (e-cigarettes) can reduce the short-term negative health effects of smoking. In adult smokers unwilling or unable to quit, exhaled carbon monoxide levels, total number of cigarettes smoked, and exposure to nitrosamine chemicals were reduced within a 12-...

Cholangiocarcinoma (CCA) is a major public health problem in the northeastern part of Thailand where the prevalence of this cancer is highest in the world. It is a slow growing tumor but highly metastatic with a poor prognosis. The traditional habit of eating raw fish, repeated exposure to liver fluke and consumption of nitrosamine-contaminated food are major risk factors. Understanding of carc...