A series of 5 para-substituted alpha-methylstyrene oxide derivatives have been synthesized and together with alpha-methylstyrene oxide as well as styrene oxide have been studied as to their mutagenicity with the TA100 and TA1535 strains of Salmonella typhimurium. A multiple regression analysis model has been developed which describes the mutagenicity of the alpha-methylstyrene oxides in TA100. ...

In 1969, a group of scientists concerned with the health hazards posed by environmental mutagens formed the Environmental Mutagen Society to encourage interest in and the study of mutagens in the human environment. In order to deal effectively with this potential health problem, these scientists saw the need for a centralized source of published information on chemicals tested for mutagenicity ...

The Salmonella mutagenicity test was used to analyze cervical mucus specimens from 364 smokers and 333 nonsmokers to determine whether the association between smoking and mutagenic cervical mucus that we reported previously among women diagnosed with dysplasia would apply to a larger group of healthy women (E. A. Holly et al., J. Natl. Cancer Inst., 76: 983-986, 1986). Women smokers and nonsmok...

Within an EU-funded research project, 281 textile dye products in use at nine textile finishing companies from eight European countries were assessed for potential mutagenic properties. Most of the dyes belonged to the so-called existing substances. Data sources considered were data published in the literature, unpublished industrial data provided by dye producing companies, and laboratory test...

The mutagenicity of 12 cycloaliphatic epoxides was investigated using the Ames Salmonella assay without the addition of liver homogenate fractions. Base-pair substitution mutagenic activity was detected for 8 members of this series of compounds, confirming our laboratory's previous observations of weak mutagenic response at high dose levels for cis-1,2-disubstituted epoxides. While mutagenicity...

With the growing number of new exhaust after-treatment systems, fuels and fuel additives for internal combustion engines, efficient and reliable methods for detecting exhaust genotoxicity and mutagenicity are needed to avoid the widespread application of technologies with undesirable effects toward public health. In a commonly used approach, organic extracts of particulates rather than complete...

a lot of chemicals such as poly (amidoamine) ( pamam - nh2 ) dendrimers have pharmaceutical applications, but the major problem with pamam - nh2 is their cytotoxicity and mutagenicity. in this research, we have investigated the cytotoxicity and mutagenicity of various generations of pamam-nh2 (g2.0, g3.0, g4.0, and g5.0). the cytotoxicity of pamam-nh2 at the dilutions of 0.01, 0.001 and 0.0001(...

The degradation of Reactive Yellow 18 (RY-18), induced by gamma radiation in aqueous medium, was carried out as a function dose (5–20 kGy) and concentration hydrogen peroxide, the initial dye pH solution were optimized for maximum efficiency. Gamma radiations alone combination with H2O2 used to degrade RY-18. A rate 99% achieved using an absorbed 20 kGy, 0.6 mL acidic pH. Variations functional ...

in this study, we investigate the potential of moricandia arvensis methanol leaf extract (meohl) on calpain activity, melanin biosynthesis and dna mutagenicity. cytotoxic effect and measurement of reactive oxygen species (ros) induced by lucigenin in colorectal cells (be) were also determined. in addition the chemical analysis of the extract was also studied and the chemical profile illustrates...

background: agriculture is an important sector for the malaysian economy. the use of pesticides in agriculture is crucial due to its function in keeping the crops from harmful insects. children living near agricultural fields are at risk of pesticide poisoning. objective: to evaluate the genotoxic risk among children who exposed to pesticides and measure dna damage due to pesticides exposure. m...