Sir, Mixed connective-tissue disease (MCTD) is a rheumato-logical disorder which has combined features of systemic lupus erythematosus, systemic sclerosis (SSc), polymyositisu dermatomyositis, and rheumatoid arthritis (RA) with anti-bodies to U 1 small nuclear ribonucleoprotein (U 1 snRNP). Although renal involvement was considered to be rare in the initial description w1x, several studies demo...

Connective tissue diseases are a rare and poorly understood etiology of trigeminal neuropathy. In a retrospective multicentric study covering 12 years. 12 cases were identified in the archives of the Departments of Neurology, Rheumatology and Internal Medicine: 4 were associated with progressive systemic sclerosis. 4 with mixed connective tissue diseases and 4 with Sjögren's syndrome. In 9 of t...

We report a case of 51 years old woman who suffered from mixed connective tissue disorder (MCTD), complicated by neuropsychiatric manifestation at her initial course of illness. This convoluted her case management, unless the diagnosed was confirmed by skin biopsy. She improved significantly and rapidly on steroid pulse. Neuropsychiatric characteristics are not common presentation in MCTD. Ther...

Trimethoprim-Sulfamethoxazole (TMP-SMZ) is associated with severe hepatic toxicity or liver failure. We present a case of severe hepatic toxicity for whom TMP-SMZ was prescribed as part of treatment for mixed connective tissue disease (MCTD). TMP-SMZ was used to prevent complications from steroid therapy, but fever and hepatic toxicity developed with repeated TMP-SMZ medication. While the drug ...

While the cause of connective tissue diseases (CTDs) remains unknown the classification of individual patients will continue to depend on identifying certain patterns of clinical and laboratory features. This is the basis of the various classification criteria for systemic sclerosis,'l systemic lupus erythematosus (SLE),2 and other connective tissue diseases. As many as 25% of patients with CTD...

Raynaud's phenomenon, fatigue and pain (myalgia and arthralgia) are important presenting symptoms of pediatric-onset mixed connective tissue disease. The difficulty is that many adolescent girls complain of pain along with fatigue without evidence for serious disease. However, in patients with Raynaud's phenomenon one should search for evidence of connective tissue diseases. Capillaroscopy coul...

regarding to the important of pancreas in the body, this study was carried out on the histologic structure of pancreas of 6 pairs of iranian native turkeys of both sexes, age ranging from 26-30 weeks. routine histological techniques were used and stained by h&e; and masson’s trichrome, gomori’s method for reticulum, verhoeff’s, maldonado’s methods. the pancreas was covered with a thick dense co...