نتایج جستجو برای: mir 103a 3p

تعداد نتایج: 49246  

2016
Vanmathy Kasimanickam John Kastelic

Sperm contain microRNAs (miRNAs), which may have roles in epigenetic control. Regarding phylogenetic relationships among various swine breeds, Yorkshire and Landrace, are considered phenotypically and genetically very similar, but distinctly different from Duroc. The objective of the present study was to compare abundance of boar sperm miRNAs in these three breeds. Overall, 252 prioritized miRN...

Journal: :JCSM rapid communications 2021

Background Cachexia is a debilitating complication of cancer characterized by progressive wasting and weakness skeletal muscles that reduces quality life can compromise survival. Many anticancer treatments, such as chemotherapy, also cause muscle wasting, which impairs the response to treatment. Given many patients present with cachexia at initiation treatment, we investigated whether cachectic...

Journal: :General Physiology and Biophysics 2021

Circular RNAs (circRNAs) have been implicated in the pathology of osteoarthritis (OA). Nevertheless, precise actions circRNA protein kinase C eta (circ-PRKCH, hsa_circ_0032131) on OA pathogenesis are still undiscovered. Cell viability and apoptosis were determined using Counting-8 Kit (CCK-8) assay flow cytometry, respectively. The levels circ-PRKCH, microRNA (miR)-140- 3p a-disintegrin metallo...

Journal: :Cardiovascular research 2015
Mengwen Yan Chen Chen Wei Gong Zhongwei Yin Ling Zhou Sandip Chaugai Dao Wen Wang

AIMS Growing evidences indicate that microRNAs (miRNAs) are involved in cardiac hypertrophy development. Multiple miRNAs have been identified as diagnostic and prognostic biomarkers of cardiac hypertrophy, as well as potential therapeutic tools. The present study aimed to investigate the functions and regulatory mechanisms of miR-21-3p in cardiac hypertrophy. METHODS AND RESULTS Decreased exp...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Xiaoming Qi Jianqiang Li Changbo Zhou Chunlei Lv Min Tian

BACKGROUND/AIMS An increasing number of studies show that microRNAs (miRNAs) play crucial roles in nasopharyngeal carcinoma (NPC) tumorigenesis. The aim of our study was to investigate the biological roles and mechanisms of miR-142-3p in NPC. METHODS miR- 142-3p expression was examined in NPC specimens and nasopharyngitis biopsy samples by quantitative real-time PCR. The biological functions ...

Journal: :Molecular cancer research : MCR 2014
Bo Guo Liying Liu Jiayi Yao Ruili Ma Dongmin Chang Zongfang Li Tusheng Song Chen Huang

UNLABELLED Results from recent studies suggest that aberrant microRNA expression is common in numerous cancers. Although miR-338-3p has been implicated in hepatocellular carcinoma, its role in gastric cancer is unknown. To this end, we report that miR-338-3p is downregulated in both gastric cancer tissue and cell lines. Forced expression of miR-338-3p inhibited cell proliferation and clonogenic...

Journal: :International journal of oncology 2015
Chunyan Wen Xiaojun Liu Hongxi Ma Wenjie Zhang Haifeng Li

miR‑338‑3p, a recently discovered miRNA, has been shown to play important roles in tumorigenesis and metastasis in various cancers. However, the exact roles and mechanisms of miR‑338‑3p remain unknown in human ovarian epithelial carcinoma (EOC). The relationship between miR‑338‑3p expression pattern and clinicopathological features of patients with EOC were determined by real-time quantitative ...

2018
Ping Wang Li Zhang Junhui Zhang Gangshu Xu

MicroRNAs (miRs) serve a role in promoting and suppressing tumors in various types of malignant cancer, such as cervical cancer. However, the regulatory mechanism of miR-124-3p in cervical cancer remains unclear. In the present study, miR-124-3p was significantly downregulated in cervical cancer tissues and cell lines compared with matching adjacent non-tumor tissues and the normal cervical epi...

2017
Qing Wang Siyang Liu Xitong Zhao Yuan Wang Dali Tian Wenjun Jiang

The aim of this study was to study the role of miR-372-3p in lung squamous cell carcinoma (LSCC) cell proliferation and invasion by suppressing FGF9. RT-PCR was used to determine miR-372-3p and FGF9 mRNA expression in tissues and cells. Western blot was used to determine FGF9 expression in tissues and NCI-H520 cell line. Dual luciferase reporter gene assay was conducted to confirm that FGF9 can...

2018
Yajie Cui Fengqin Wu Defu Tian Ting Wang Tianjie Lu Xiying Huang Peilian Zhang Li Qin

Drug resistance remains a large obstacle for the treatment of ovarian cancer. miRNAs have been reported to be involved in cisplatin (CDDP) resistance in ovarian cancer. The aim of the present study was to investigate the function and mechanism of miR-199a-3p in the CDDP resistance in ovarian cancer. We found that miR-199a-3p was significantly downregulated in chemoresistant ovarian cancer tissu...

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