Glavonoid-rich oil (GRO) derived from ethanol extraction of licorice (Glycyrrhiza glabra Linne) root has been reported to have beneficial effects on health. In this study, we aimed determine the effect long-term administration GRO metabolic disorders and elucidate molecular mechanism. Female obese, type 2 diabetic KK-Ay mice were fed diets supplemented with 0.3% or 0.8% (w/w) for 4–12 weeks. Mi...

Abstract TREX1 (DNase III) is the major mammalian 3’-5’ DNA exonuclease and thought to play a role in cell death genomic degradation. Dysfunction of Trex1 has been suggested activate immune response by self DNA, as null mice develop inflammatory myocarditis similar autoimmune cardiomyopathy produce type 1 IFN. D18N causes monogenic cutaneous form lupus called familial chilblain exhibits dysfunc...

The clinical characterization of small hepatocellular carcinoma (HCC) lesions in the liver and differentiation from heterogeneous inflammatory or fibrotic background is important for early detection treatment. Metabolic monitoring hyperpolarized 13C-labeled substrates has been suggested as a new avenue diagnostic magnetic resonance. metabolism [1-13C]pyruvate was monitored mouse precision-cut s...

Perinatal exposure to nicotine imbalances the redox status in newborns. This study investigated effect of Anethum graveolens (dill) extract on oxidative stress and tissue injury liver kidney mice newborns exposed perinatally. Pregnant received (0.25 mg/kg) gestational day 12 5 after birth and/or A. 1 15 birth. Newborn showed multiple histopathological alterations liver, including inflammatory c...

Drug induced liver injury (DILI) leads to acute hepatitis in 10%, liver failure, and death in 30%. One of the major drugs causing DILI is Anti-tuberculous drugs and since tuberculosis is affecting 1/3rd of the total world population, their use is quite common. Use of Isoniazid (INH) is limited owing to hepatotoxicity following the stress produced by oxidative species. Silymarin has hepatoprotec...

To determine the effects of plant-based meat analogues on metabolic health and possible mechanisms, mice were fed with a real pork diet (AP), beef (AB), analogue (PP) (PB) for 68 days. Compared meat, increased food energy intake, body weight, white fat liver weight caused adipocyte hypertrophy, hepatic lipid droplet accumulation, more severe inflammatory responses in mice. Metabolomics revealed...

Background: Chamomile essential oil (CEO) hauls out from Matricaria chamomilla L., is a well-known anti-oxidant. Oxidative stress induces clastogenic and biochemical disorders after γ-irradiation of animals. Materials and Methods: Mice were divided into five groups. Control group received vehicle only.              &nbs...

Objective(s) Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2), comprise a group of small extracellular proteins with a common P-sheet-dominated 3-dimensional structure. In the past, it was assumed that the predominant role of lipocalin was acting as transport proteins. Recently it has been found that oxidative stress induces Lcn2 expression. It has been also proved that electromagnetic f...