Background: We earlier reported that datumetine possesses binding affinity with NMDAR and that 14-day exposure to datumetine altered NMDAR signalling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. Results: Relative to Veh, datumetine downregulate the expression of CamKIIα i...

Background: The characteristics of glioblastoma, such as drug resistance during treatment, short patient survival, and high recurrence rates, have made patients with glioblastoma more likely to benefit from oncolytic therapy. Methods: In this study, we investigated the safety sindbis virus by injecting intravenously intracranially in mice evaluated therapeutic effect carrying different combinat...

Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of cannabis plant and an exogenous ligand endocannabinoid system. In previous studies, we demonstrated that a single microdose THC (0.002 mg/kg, 3–4 orders magnitude lower than standard dose for rodents) exerts distinct, long-term neuroprotection in model mice subjected to acute neurological insults. When administered old, ...

Abstract Rab27 is a GTPase involved in the biogenesis of extracellular vesicles (EVs) and cellular secretion pathway. Among two isoforms (a b) Rab27a has been identified regulating angiogenesis during development wound healing via VEGFR1. Here, we show that plays role stability brain vasculature including pathological glioblastoma.. Thus, relative to wild-type C57bl/6 (WT) double heterozygous R...

Purpose: To investigate the neuroprotective effect of erythropoietin (EPO) against hypoxic-ischemic brain injury in neonatal mice, and underlying mechanism(s) action.
 Methods: Sixty mice were assigned to 3 groups: sham, model EPO intervention groups, each with 20 mice. Western blot assay was used determine changes protein expressions AMPK, UCP2 KLF2. Fluorescence intensity reactive oxygen...

In the present study, effects of Origanum onites L. extract and essential oil O. on antioxidant status liver brain mice were investigated. Due to certain disadvantages oils, such as poor solubility, high volatility sensitivity UV light heat, formulation liposomes with Oregano essentials (OE) was optimized used in this study. The results demonstrated that best composition lipid carriers OE condu...

Abstract It is important to determine the functional changes of organs that occur as a result aging, understanding which may lead maintenance healthy life. Glucose metabolism in bodies one potential markers used evaluate organ function. Thus, information about normal glucose help understand organs. [ 18 F]-Fluoro-2-deoxy-2- d -glucose ( F-FDG), analog, has been measure various fields, such basi...

Abstract Desvenlafaxine succinate (DVS) inhibits serotonin reuptake selectively and is approved for major depressive disorders. This research investigated influence of DVS on modulating brain monoamine oxidative stress in mice. The antiepileptic potential (10, 20, or 30 mg/kg/i.p.) pentylenetetrazole (PTZ; 85 mg/kg) with i.p. route administration, strychnine (STR; 75 route, pilocarpine (400 s.c...

Abstract We recently found a significant association between exonic copy-number variations in the Rho GTPase activating protein 10 ( Arhgap10 ) gene and schizophrenia Japanese patients. Special attention was paid to one patient carrying missense variant (p.S490P) exon 17, which overlapped with an deletion other allele. Accordingly, we generated mouse model S490P/NHEJ mice) coexisting frameshift...

Fluoride which is widespread in our environment and food due to its geological origin industrial pollution has been identified as a developmental neurotoxicant. Gut-brain axis provides new insight into brain-derived injury. We previously found the psychoactive effects of probiotic strain, Lactobacillus johnsonii BS15 against fluoride-induced memory dysfunction mice by modulating gut-brain axis....