Smartphone has become an integral part of our lives, they generally have a small screen because which it is more likely to induce slouched posture creating line sight mostly below eye level, formulating improper when used for prolonged period time, example, forward head (FHP) leading neck pain. The purpose the study compare effectiveness Deep flexor strengthening exercises with that McKenzie ex...

There is a strong similarity between the expansions of the heat kernel as worked out by people in Riemannian geometry in the seventies (starting with the famous “Can one hear the shape of a drum” by Mark Kac [Kac], the Berger paper [Berger] and the Mc-Kean-Singer paper [McK-Si]) and the so-called semi-classical trace formulas developed by people in semi-classical analysis (starting with Helffer...

Rad is a low molecular weight GTPase that is overexpressed in skeletal muscle of some patients with type 2 diabetes mellitus and/or obesity. Overexpression of Rad in adipocytes and muscle cells in culture results in diminished insulin-stimulated glucose uptake. To further elucidate the potential role of Rad in vivo, we have generated transgenic (tg) mice that overexpress Rad in muscle using the...

The product of the retinoblastoma tumor suppressor gene (Rb) can control cell proliferation and promote differentiation. Murine embryos nullizygous for Rb die midgestation with defects in cell cycle regulation, control of apoptosis, and terminal differentiation of several tissues, including skeletal muscle, nervous system, and lens. Previous cell culture-based experiments have suggested that th...

Hyperplasia or hypoplasia of muscles gradually leads to strabismus. Myogenesis-related genes are involved in extraocular muscle development, including myogenic differentiation 1 (MYOD1), myogenin (MYOG), retinoblastoma 1 (RB1), cyclin-dependent kinase inhibitor 1A (P21), cyclin‑dependent kinase inhibitor 1C (P57), insulin-like growth factor 1 (IGF1) and muscle creatine kinase (MCK). This study ...

1x. E. Darzynkiewicz. Z. Karimierczuk and D. Shugar. Ctrrrcer Bio(.h~‘/t7. Biophys. 1. 203 (1976). E. De Clercq. E. Darrynkiewicz and D. Shugar, Bioc/retrr. P/~u~uu. 24. 523 (1975). M. Fiala. A. W. Chow, K. Miyasaki and L. B. Guze. J. /r~fec,t. Dis. 129. 82 (1974). M. I. Marks. .4rltirnicroh. Ay. Chrmother. 6, 34 (1974). E. R. Kern. J. C. Overall. Jr. and L. A. Glasgow, Antim~cwh. A!/. Cl~rrtro...

Murine cytomegalovirus encodes numerous proteins that act on a variety of pathways to modulate the innate and adaptive immune responses. Here, we demonstrate that a chemokine-like protein encoded by murine cytomegalovirus activates the early innate immune response and delays adaptive immunity, thereby impairing viral clearance. The protein, m131/129 (also known as MCK-2), is not required to est...

The positive regulatory domain containing 16 (PRDM16) is commonly regarded as a "switch" controlling the transdifferentiation of myoblasts to brown adipocytes. The N-positive regulatory (PR) domain, which is highly homologous to SET domain, is a characteristic structure for the PRDM family. Many SET domain containing proteins and several PRDM members have been found to possess histone methyltra...