Placental malaria is a common clinical complication during pregnancy and is associated with abortion, premature delivery, intrauterine growth retardation and low birth weight. The present study was designed to delineate the underlying mechanism of placental pathology during malarial infection with special reference to oxidative stress and apoptosis. Experimentally, pregnant BALB/c mice were inf...

Malaria is a vector–borne infectious disease caused by five protozoan parasite species of the Plasmodium, the most serious forms of the disease are caused by P. falciparum. Other species are P. vivax, P. ovale and P. malariae caused milder disease in humans that is not generally fatal. A fifth specie P. knowelsi, cause malaria in macaques but can also infect humans. It is wide spread on tropica...

perfectly different, and, in his present paper, unexplained causation. We venture to think that the reasons advanced by him in favor of this theory are insufficient, and the so-called facta in many cases inaccurate when tested by the touchstone of actual experience. Before replying in detail to the arguments brought forward by Dr. O'Connell we desire to draw attention to the extremely valuable ...

By J. Slane, l.r.c.p. In the month of June or July of 1S81, you were kind enough to publish in your journal a case of so-called malarial cachexia, which I had reported to you. Since then a lady has twice come under my care with symptoms of a kindred character, and whose case, as briefly detailed below, I beg leave to send you for publication. Mrs. aged 35 years, of full habit, nervous temperame...

Experimental malarial thrombocytopenia can reach life-threatening levels and is believed to be due to Abs targeting platelets for destruction by the reticuloendothelial system. However, we report that Abs account for at most 15% of platelet destruction as Plasmodium berghei-infected B cell-deficient mice exhibited profound thrombocytopenia (83%) as did C57BL/6 controls (98%). Further, no signif...

Malaria is a pathogenic infection caused by protozoa of the genus plasmodium. It is mainly confined to sub-Saharan Africa, Asia and South America. This disease claims the life of over 1.5 to 2.7 million people per year. Owing to such a high incidence of malarial infections, there is an urgent need for the development of suitable vaccines. For the development of ideal vaccines, it is essential t...

Isolation and characterisation of Plasmodium falciparum (Welch, 1897) soluble antigens from infected patient plasma, Western blotting, thermal stability and ELISA assays using hyperimmune IgG-antimalaria antibodies was the main objective of this work. A circulating antigen of approximately Mr 33-35 kDa with good specificity and antigenicity, in the plasma of malarial patients was shown. Heating...