A marked tissue-specific increase in erythrocyte adenosine deaminase (ADA) activity is associated with an autosomal dominantly inherited hemolytic anemia. We investigated the molecular basis of ADA overproduction by studying reticulocyte ADA mRNA from affected individuals. Analysis of proband reticulocyte ADA cDNA clones revealed normal sequence. RNase mapping demonstrated that the amount of AD...

apparent with a physiological level of glucocorticoids of about 0.3 @tMin humans, as shown in experiments on hepatoma cells (4) and L5i 78Y cells(6)in vitro,Factor1 maypossiblyenhance the effect of physiological levels of glucocorticoid in vivo and thus may itself have the therapeutic effects of glucocorticoid. In this work, we examine (a) the effect of Factor 1 on the growth inhibition by gluc...

A 2-year-old female shorthair guinea pig was presented to the Veterinary Medical Teaching Hospital, University of Wisconsin-Madison, for evaluation of a unilateral corneal opacity of 1 week duration. Physical examination revealed a markedly thickened right cornea and lymphadenopathy of the submandibular and prescapular lymph nodes. Cytology of a lymph node aspirate was highly suggestive of lymp...

A human serum (obtained from a multiparous and multiple-transfused patient with chronic myelogenous leukemia) and a rabbit antiserum (obtained by immunization with papain extracts from a B-lymphoblastoid cell line) showed reactivity against antigenic specificities (different from HLA) expressed on peripheral blood B-lymphocytes, unmarked lymphocytes, and monocytes. These antigenic determinants ...

Hematogones are the normal bone marrow constituents of bone marrow in children and their number decreases with age. As hematogones can resemble malignant lymphoblasts by their morphologic features and by expression of an immature B-cell phenotype, an accurate distinction of hematogone-rich lymphoid regeneration from leukemic lymphoblasts is critical for patient care. The increased number of hem...

The purpose of this report is to compare measurements of enzymatic activities and cell surface markers as methods of distinguishing subtypes of lymphoid leukemias of childhood. Twenty-six children ages 2-15 yr were studied. Terminal deoxynucleotidyl transferase (TdT) activity was high in blasts from all 20 children with either null or T cell acute lymphoblastic leukemia. The activity of adenosi...

The field of neural networks has seen significant advances in recent years with the development deep and convolutional networks. Although many current works address real-valued models, studies reveal that hypercomplex-valued parameters can better capture, generalize, represent complexity multidimensional data. This paper explores quaternion-valued network application for a pattern recognition t...