The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of exposure. In this article, we demonstrate how a PBPK model can be constructed b...

this study was carried out at the razi institute during 2005-2006 with inspecting 12168 lung tissue of slaughtered sheep and goats at the ziaran abattoir. pneumonia were diagnosed in 282 cases and the affected lung tissue was collected and transferred to the bacteriology and pathology departments for isolating of pasteurella spp. and interpretation of histopathologic lesions. pasteurella multoc...

introduction radon is a colorless and tasteless gas which exists in most soils. it is a substance that poses a potential risk for lung cancer in case a person is exposed to high levels over long periods of time. the environmental protection agency (epa) estimates that 90% of lung cancers per year are caused by radon. the aim of this paper is to estimate the absorbed doses of 222rn by mcnpx simu...

  This study was carried out at the Razi Institute during 2005-2006 with inspecting 12168 lung tissue of slaughtered sheep and goats at the Ziaran Abattoir. Pneumonia were diagnosed in 282 cases and the affected lung tissue was collected and transferred to the Bacteriology and Pathology Departments for isolating of Pasteurella spp. and interpretation of histopathologic lesions. Pasteurella mult...

The neutron therapy facility at the Gershenson Radiation Oncology Center, Harper University Hospital in Detroit has been operational since September 1991. The d(48.5)+Be beam is produced in a gantry mounted superconducting cyclotron designed and built at the National Superconducting Cyclotron Laboratory (NSCL). Measurements were performed in order to obtain the physical characteristics of the n...

Background: Thermoluminescence dosimetry is one of the dosimetry procedures used widely as routine and personal dosimeters. In order to extend this kind of dosimeters, dental tissue has been examined and was found promising as a TLD dosimeter. Materials and Methods : In this study, 70 health teeth were collected. The only criterion, which was considered for selection of the teeth, was the healt...

UNLABELLED (131)I-metaiodobenzylguanidine (MIBG) is specifically taken up in neuroblastoma, with a response rate of 20%-37% in relapsed disease. Nonradioactive carrier MIBG molecules inhibit uptake of (131)I-MIBG, theoretically resulting in less tumor radiation and increased risk of cardiovascular toxicity. Our aim was to establish the maximum tolerated dose of no-carrier-added (NCA) (131)I-MIB...

Synthetic diamond is potentially one of the more interesting materials in the field of detectors applicable in dosimetry. It is, in fact, tissue equivalent (its atomic number, Z = 6, is very close to the actual atomic number of a biological tissue, Z = 7.5. Moreover it is not toxic and shows a high resistance to radiation damage, a high sensitivity and stability of response, a low leakage curre...