The ability of ketamine, phencyclidine and analogues to alter catecholamine secretion from cultured bovine adrenal chromaffin cells was investigated. Both ketamine and phencyclidine specifically inhibited nicotinic agonist-induced secretion at concentrations which did not alter secretion induced by elevated K+ depolarization. The inhibition of nicotinic agonist-induced secretion was not overcom...

This study compares sentinel lymph-node biopsy carried out at the time of removal of the primary breast tumour, under general anaesthetic, with sentinel lymph-node biopsy carried out under local anaesthetic prior to the main operation. It compares the total cost of the two treatment approaches, in terms of average income and of their impact on the subsequent programming of operations and hence ...

Breast reduction is one of the most commonly performed plastic surgery procedures, and pedicle deepithelialization remains a time-consuming step of the operation. This is especially true when using an inferior pedicle. We present a novel technique of intradermal infiltration of the breast pedicle with local anesthetic to facilitate efficient, bloodless deepithelialization. The senior author use...

The Wide-Awake Approach to Dupuytren's contracture involves fasciectomy under local anesthetic with epinephrine and no tourniquet. The goal of this study is to show that the Wide-Awake Approach produces equivalent outcomes to fasciectomy under general anesthetic with a tourniquet, with fewer risks to the patient. A multicenter retrospective review was conducted on 111 patients with fasciectomie...

Local anesthetic infiltration prior to surgical incision closure is a frequently used technique in the operating room. Debate continues, with clinicians, as to the effectiveness of this technique in pain reduction. A literature review using PubMed with the criteria of "local anesthetic infiltration and pain reduction" was conducted for the use of local anesthetic infiltration prior to surgical ...

With respect to the membrane lipid theory as a molecular mechanism for local anesthetics, two critical subjects, the negligible effects of charged drugs when applied extracellularly and the stereoselective effects of enantiomers, were verified by paying particular attention to membrane components, phospholipids with the anionic property, and cholesterol with several chiral carbons. The membrane...

BACKGROUND Several studies have suggested that the likelihood of paresthesia may depend on the local anesthetic used. The purpose of this study was to determine if the type of local anesthetic administered had any effect on reports of paresthesia in dentistry in the United States. METHODS The authors obtained reports of paresthesia involving dental local anesthetics during the period from Nov...

Meperidine (Demerol) has local anesthetic properties separate from its opioid receptor agonist effect. Unlike morphine, meperidine is structurally similar to local anesthetics. Therefore, it is not surprising that it possesses some characteristics of local anesthetics. If meperidine acts like a local anesthetic, binding to the same receptor sites and inhibiting nerve conduction, then drugs that...

Botulin toxin type A (BoNT-A) has been demonstrated as an effective prophylactic treatment of primary headache disorders.1 The results of the experimental studies of Durham et al suggested that the efficacy of BoNT-A in the management of migraine is due, in part, to its capacity in blocking the release of calcitonin gene-related peptide (CGRP) from the trigeminal neurons.2 In his commentary, Bl...

propofol. We have subset the original dataset to the 2,210 patients who received one of those regimens and report a regression-based analysis as well as a propensity-matching analysis. Table 3 shows the comparison between regimens midazolam plus etomidate and midazolam plus propofol among the subset of patients who received one of the regimens using the suggested propensity-matching approach an...