High prevalence of diabetes mellitus in patients with liver cirrhosis has been reported in many studies. The aim of our study was to evaluate the relationship of hepatic fibrosis and steatosis assessed by transient elastography with diabetes in patients with chronic liver disease. The study population consisted of 979 chronic liver disease patients. Liver fibrosis and steatosis were assessed by...

BACKGROUND To assess the clinical validity of controlled attenuation parameter (CAP) in the diagnosis of hepatic steatosis in a series of overweight or obese children by using the imperfect gold standard methodology. METHODS Consecutive children referred to our institution for auxological evaluation or obesity or minor elective surgery were prospectively enrolled. Anthropometric and biochemic...

Neonatal hepatic steatosis (OMIM 228100) is a fatal condition of unknown etiology characterized by a pale and yellow liver and early postnatal mortality. In the present study, a deficit in adenosine-dependent metabolism is proposed as a causative factor. Physiologically, adenosine is efficiently metabolized to AMP by adenosine kinase (ADK), an enzyme highly expressed in liver. ADK not only ensu...

BACKGROUND The mechanisms underlying steatosis during hepatitis C virus (HCV) infection are complex and multifactorial. The aim of our study was to assess whether host metabolic factors influence the degree of hepatic steatosis and fibrosis in patients infected with hepatitis C virus genotype 4 by investigating the role of adiponectin, leptin and insulin resistance. METHODS Adiponectin and le...

We read the article by Garjani et al. (1) with great interest. In this study, they demonstrated that patients with moderate or severe fatty liver disease on ultrasonography had higher platelet counts than those with mild fatty liver and concluded that platelet counts could be used as a clue to steatosis grade of nonalcoholic fatty liver disease (NAFLD). Low platelet counts are frequently observ...

Curcumin is a polyphenol extracted from the rhizome of turmeric, and our previous research showed that curcumin inhibited cholesterol absorption had cholesterol-lowering effect. Bisphenol A (BPA), common plasticizer, widely used in manufacture food packaging associated with non-alcoholic fatty liver disease (NAFLD). We hypothesized could protect against BPA-induced hepatic steatosis by inhibiti...

Abstract Background The SAF score (steatosis, activity, and fibrosis) has been developed for the assessment of histological severity nonalcoholic fatty liver disease (NAFLD) steatohepatitis (NASH). aim this study was to assess usefulness in a homogenous cohort Egyptian patients with chronic HCV infection (CHC) without any alcohol consumption cirrhosis. We performed prospective cross-sectional i...

BACKGROUND & AIMS A novel controlled attenuation parameter (CAP) using the signals acquired by the FibroScan® has been developed as a method for evaluating steatosis. The aim of this study is to assess the performance of the CAP for the detection and quantification of steatosis in patients with chronic hepatitis B (CHB). MATERIAL AND METHODS 136 subjects with CHB underwent liver biopsy and Fi...

Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of triglycerides in the hepatocytes of patients who don’t abuse alcohol. It ranges in severity from simple steatosis (excessive fat accumulation) to steatohepatitis (liver cell injury and inflammation). Nonalcoholic steatohepatitis (NASH) is a subtype of NAFLD in which steatosis coexists with steatohepatitis. NASH can...

Non-alcoholic fatty liver disease (NAFLD) is mainly characterized by excessive fat accumulation in the liver. It spans a spectrum of diseases from hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Brassica juncea rich glucosinolates has been proven possess many potential pharmacological properties, including hypoglycemic, anti-ox...