نتایج جستجو برای: intracortical
تعداد نتایج: 2386 فیلتر نتایج به سال:
A recent study has found that spontaneous neural activity in the developing visual cortex has two distinct origins - local intracortical circuits and spontaneous activity in the retina.
BACKGROUND Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders causing learning disabilities by mutations in the neurofibromin gene, an important inhibitor of the RAS pathway. In a mouse model of NF1, a loss of function mutation of the neurofibromin gene resulted in increased gamma aminobutyric acid (GABA)-mediated inhibition which led to decreased synaptic plasticity and...
27 A high dose of sodium salicylate temporarily induces tinnitus, mild hearing loss, and 28 possibly hyperacusis in humans and other animals. Salicylate has well-established effects on 29 cochlear function, primarily resulting in the moderate reduction of auditory input to the brain. 30 Despite decreased peripheral sensitivity and output, salicylate induces a paradoxical 31 enhancement of the s...
Peripheral sensory afferents in the hand activate both excitatory and inhibitory intracortical circuits to potentially facilitate and prune descending motor commands. In this study, we characterized how afferent inputs modulate the excitability of cortical circuits in the leg area of the primary motor cortex by examining how stimulation of the tibial nerve (TN) at the ankle alters motor evoked ...
20 Activation of nicotinic acetylcholine receptors (nAChRs) by systemic nicotine enhances sensory21 cognitive function and sensory-evoked cortical responses. Although nAChRs mediate fast 22 neurotransmission at many synapses in the nervous system, nicotinic regulation of cortical 23 processing is neuromodulatory. To explore potential mechanisms of nicotinic neuromodulation, 24 we examined wheth...
The present study aimed to further investigate whether the intracortical neural circuits within the primary motor cortex (M1) are modulated during ipsilateral voluntary finger movements. Single- and paired-pulse (interstimulus intervals, ISIs; 3 ms and 12 ms) transcranial magnetic stimulations of the left M1 were applied to elicit motor evoked potential (MEP) in the right first dorsal interosse...
In this and the subsequent companion paper, results are presented that collectively seek to delineate the contribution that supraspinal circuits have in determining the time to task failure (TTF) of sustained submaximal contractions. The purpose of this study was to compare adjustments in supraspinal and spinal excitability taken concurrently throughout the performance of two different fatigue ...
Previous studies examining the influence of afferent stimulation on corticospinal excitability have demonstrated that the intensity of afferent stimulation and the nature of the afferents targeted (cutaneous/proprioceptive) determine the effects. In this study, we assessed the effects of whole-hand water immersion (WI) and water flow stimulation (WF) on corticospinal excitability and intracorti...
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