نتایج جستجو برای: intestinal drug delivery

تعداد نتایج: 868479  

2014
Deepak Kumar Palak Kapoor

The oral delivery of drugs having narrow absorption window in the gastro-intestinal tract is limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the time of absorption. To provide controlled delivery of drugs novel drug delivery systems have been developed. Different systems have been developed to increase the gastric residen...

Journal: :iranian journal of pharmaceutical research 0
xiahui peng department of bioengineering and environmental science, changsha university, changsha 410003, china. qiang zhuang school of chemistry and chemical engineering, central south university, changsha 410083, china. dongming peng school of pharmacy, hunan university of chinese medicine, changsha 410208, china. qiuli dong school of chemistry and chemical engineering, central south university, changsha 410083, china. lini tan school of chemistry and chemical engineering, central south university, changsha 410083, china. feipeng jiao school of chemistry and chemical engineering, central south university, changsha 410083, china.

in this paper, carbon nanotubes (cnts) were added into chitosan (cs) hydrogels in the form of chitosan modified cnts (cs-cnts) composites to prepare carbon nanotubes hydrogels (cnts-gel). the products, named cs-mwcnts, were characterized by scanning electron microscope (sem) and fourier transform infrared (ftir) spectroscopy. swelling properties and effect of ph on controlled release performanc...

Journal: :journal of physical and theoretical chemistry 0
z. yousefian department ofchemistry, north tehran branch, islamic azad university, tehran, iran

in this work, we have studied binding of clonidine drug (c9h9cl2n3) with zigzag single walled carbonnanotubes (swcnt) (5, 0) by theoretical methods of theory using gaussian 09 software package.binding energies, nmr parameters and homo- lumo gap energy were calculated. results frombinding energies indicate that it is possible thermodynamically to bind clonidine drug to swcnt.the calculated nmr p...

Journal: :journal of paramedical sciences 0
hassan dariushnejad department of medical biotechnology, faculty of advanced medical sciences, tabriz university of medical sciences, tabriz, iran. fatemeh karimitabar young researchers & elite club, islamic azad university, hamedan branch, hamedan, iran. masoud hamidi young researchers & elite club, islamic azad university, hamedan branch, hamedan, iran. nayeb ali ahmadi proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran.

the major limitation in the application of bioactive molecule is their low permeation across plasma membrane. in 1988 it was discovered, that a natural polycationic protein, the trans-acting activator of transcription (tat) of the human immunodeficiency virus (hiv-1), passed very efficiently through cell membrane of cultured mammalian cells. tat became known as the first cell penetrating peptid...

Journal: :nanomedicine journal 0
mitra amoli-diva department of chemistry, payam noor university (pnu), tehran, iran kamyar pourghazi department of novel medical technologies, darupakhsh pharmaceutical co., tehran, iran

objective(s): pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. researchers have intended to reformulate drugs so that they may be more safely used in human body. the more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. the aim of t...

Journal: :modares journal of medical sciences: pathobiology 2015
fereshteh atabi seyed latif mousavi gargari mehrdad hashemi parichehr yaghmaei

background: drug delivery systems related to different cancer therapy is now expanding. chitosan (cs) is currently receiving enormous interest for medical and pharmaceutical applications due to its biocompatibility in animal tissues. in this study two nanogels were prepared from chitosan. some of the critical factors such as controlling the release, adsorption and specially targeting drug deliv...

Journal: :Advanced functional materials 2016
Rasa Ghaffarian Edgar Pérez Herrero Hyuntaek Oh Srinivasa R Raghavan Silvia Muro

When administered intravenously, active targeting of drug nanocarriers (NCs) improves biodistribution and endocytosis. Targeting may also improve oral delivery of NCs to treat gastrointestinal (GI) pathologies or for systemic absoption. However, GI instability of targeting moieties compromises this strategy. We explored whether encapsulation of antibody-coated NCs in microcapsules would protect...

2010
J. Kawadkar K. Chauhan Meenakshi A. Ram

BACKGROUND AND THE PURPOSE OF THE STUDY Pectin derivatives have been utilized for colonic drug delivery (CDD). In this study the effects of different formulation variables upon the characteristics of pectinate microparticles (MPs) prepared by ionotropic gelation technique for colonic delivery of mesalazine was investigated. METHODS In-vitro drug release of MPs was studied using USP XXIV disso...

Journal: :International journal of pharmaceutics 2009
Ghanshyam V Joshi Bhavesh D Kevadiya Hasmukh A Patel Hari C Bajaj Raksh V Jasra

The need for safe, therapeutically effective, and patient-compliant drug delivery systems continuously leads researchers to design novel tools and strategies. Clay minerals play a very crucial role in modulating drug delivery. This work examines the advantageous effect of clay mineral as drug carrier for timolol maleate (TM), a nonselective beta-adrenergic blocking agent. The intercalation of T...

Journal: Current Medical Mycology 2018

Skin is an important organ of the body due to offering an accessible and convenient site for drug administration. One of the disadvantages of transdermal drug delivery is the low penetration rate of drugs through the skin. Over the past decades, nanoparticles have been used as drug delivery systems to increase therapeutic effects or reduce toxicity. Encapsulation of drugs in nanoparticulate ves...

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