Humans evolved by losing the capacity to synthesize glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in develop a protective response mediated anti-α-Gal IgM/IgG antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can alpha-Gal syndrome (AGS), recently diagnosed disease mainly associated with allergic reactions mammalian m...

INTRODUCTION M embranoproliferative glomerulonephritis (MPGN) is a pattern of injury characterized by mesangial and endocapillary proliferation, double contours along the capillary walls, and lobular accentuation of the capillary tufts. Based on pathophysiology, MPGN is classified into MPGN mediated by immune complexes and Igs and complement-mediated MPGN. Immune complex/Ig–mediated MPGN most o...

Sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. It was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. It has several adverse reactions on multi organ systems including hematologic system. Although the neutropenia and thrombocytopenia commonly happens as Gra...

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare medical emergency for which correct and early diagnosis essential. As severe deficiency in A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats, member 13 (ADAMTS13) the underlying pathophysiology, diagnostic strategies require timely monitoring of ADAMTS13 parameters to differentiate TTP from alternative mic...

sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. it was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. it has several adverse reactions on multi organ systems including hematologic system. although the neutropenia and thrombocytopenia commonly happens as gra...

Guillain-Barre syndrome (GBS) is an acute inflammatory demyelinating polyradiculoneuropathy that results from abnormal cell-mediated immune response to peripheral nerves. In about two-thirds of cases, infectious etiology precedes symptoms. GBS a rare disease during pregnancy with incidence 1.2 and 1.9 cases per 100,000 year carries high maternal risk. We report case complicating in the postpart...

Background Celiac disease (CD) is an autoimmune mediated gluten sensitive enteropathy and a chronic inflammatory condition caused by immune pathology in the small intestines in genetically susceptible individuals. This study aimed to determine the efficacy of gluten free diet on cardiac functions using conventional and Doppler tissue echocardiography (DTE) in children with CD compared to contr...

Cerebrospinal fluid (CSF) analysis is one of the most important tests in diagnosis central nervous system (CNS) diseases. Although CSF commonly used neurological pathological conditions, it also has its place psychiatry. Studies to date have described several valuable specific cytomorphological phenomena cerebrospinal patients with acute schizophrenia, which indicate inflammatory or immune-medi...

In this paper, we report a case of autism in child who was cured Kawasaki disease and the condition significantly improved. (KD), also known as cutaneous mucosal lymph node syndrome, first reported by Japanese doctor Tomaku 1967. recent years, domestic foreign studies believe that pathogenesis KD is related to infection, genetic susceptibility immune response, its treatment still need be furthe...

Significance Human cytomegalovirus (HCMV) reactivation is a major cause of posttransplant morbidity/mortality. One approach toward reducing this purging the transplant donor and/or recipient latently infected cells prior to stem-cell or organ harvest/engraftment. Our findings show involvement host bromodomain (BRD) proteins in regulation HCMV latency and reactivation. Bromodomain extra-terminal...