The involvement of all five offspring of consanguinous and hypertriglyceridemic parents (first cousins) is reported. Three sons and two daughters of this family have increased triglycerides, normal cholesterol, and normal or slightly increased phospholipids. Mother and elder daughter have abnormal glucose tolerance. Father and mother are hypertensive; father had recent development of myocardial...

There is a strong, positive, independent, continuous, graded relation between hypercholesterolemia and the risk for coronary heart disease (CAD). In clinical trials, it has been shown that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or statins inhibit HMGCoA reductase competitively, reduce LDL levels more than other cholesterol-lowering drugs and lower triglyceride leve...

BACKGROUND In some cross-sectional studies, hypertriglyceridemic waist (HTGW) has been recommended as an alternative to metabolic syndrome (MetS) for screening individuals at high risk for diabetes mellitus (DM). However, little information is about the predictive power of HTGW for future DM. The aims of the study were to assess the DM predictive power of HTGW compared with MetS based on the fo...

BACKGROUND It is unclear whether the hypertriglyceridemic waist phenotype (HTWP) can be used to identify those at most risk of cardiometabolic disorders. OBJECTIVES The utility of the HTWP as a useful predictor of cardiometabolic risk in youth stratified by body mass index was assessed. METHODS Three hundred and eighty-seven children (12-17.5 years) were used within this cross-sectional stu...

D yslipidemia in patients with diabetes has suddenly emerged as a vital clinical issue. Whereas better glucose control has not been shown to significantly reduce vascular mortality and morbidity (1), lowering LDL cholesterol has regularly been associated with substantial benefit. This may be just the beginning; fibrate therapy also holds promise (2). The Adult Treatment Panel III (ATPIII) reaff...

OBJECTIVE The effect of n-3 polyunsaturated fatty acids on the serum lipid profile in a Mexican population was evaluated. MATERIAL AND METHODS Three g of salmon oil was the daily intake during four weeks. Total cholesterol, triglycerides, low density lipoproteins, high density lipoproteins and erythrocyte fatty acid composition were analyzed. RESULTS The hypertriglyceridemic group showed a ...

Using "high-performance" anion-exchange chromatography, we isolated and quantified human C apolipoproteins (apo C) from very-low-density lipoproteins (VLDL) in serum. As revealed by isoelectric focusing and double immunodiffusion against monospecific antisera, apo C-I, apo C-II, apo C-III0, apo C-III1, and apo C-III2 were purified to homogeneity. Assay reproducibility (coefficients of variation...