نتایج جستجو برای: hydrochloride heroin

تعداد نتایج: 50020  

Journal: :The international journal of neuropsychopharmacology 2014
André Schmidt Stefan Borgwardt Hana Gerber Otto Schmid Gerhard A Wiesbeck Anita Riecher-Rössler Kerstin Bendfeldt Renata Smieskova Undine E Lang Katya Rubia Marc Walter

Neuroimaging studies have reported reduced activity in a broad network of brain regions during response inhibition in heroin-dependent patients. However, how heroin in an acute dose modulates the neural correlates of response inhibition and the underlying brain connectivity has not yet been investigated. In this double-blind placebo-controlled study, we used functional magnetic resonance imagin...

Journal: :Journal of psychopharmacology 2000
I H Franken L Y Kroon R W Wiers A Jansen

Previous studies provide evidence for the selective processing of disorder related stimuli on anxiety, depression, and eating disorders. There exist some preliminary indications that selective processing of drug cues may be involved in drug craving and relapse that deserve further investigation. In order to investigate the role of processing bias in an abnormal motivational system, the attentio...

2013
Bin Zhao Yongsheng Zhu Wei Wang Hai-min Cui Yun-peng Wang Jiang-hua Lai

The glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene that encodes the 2A subunit of the N-methyl D-aspartate (NMDA) receptor was recently shown to be involved in the development of opiate addiction. Genetic polymorphisms in GRIN2A have a plausible role in modulating the risk of heroin addiction. An association of GRIN2A single-nucleotide polymorphisms (SNPs) with heroin addiction was f...

Journal: :European Neuropsychopharmacology 2015
Gordon L.F. Cheng Yu-Pin Liu Chetwyn C.H. Chan Kwok-Fai So Hong Zeng Tatia M.C. Lee

Neurobiological investigation of heroin revealed that abusers of this highly addictive substance show dysregulation in brain circuits for reward processing and cognitive control. Psychologically, personality traits related to reward processing and cognitive control differed between heroin abusers and non-abusers. Yet, there is no direct evidence on the relationship between these neurobiological...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Joel E Schlosburg Timothy W Whitfield Paula E Park Elena F Crawford Olivier George Leandro F Vendruscolo George F Koob

The abuse of opioid drugs, both illicit and prescription, is a persistent problem in the United States, accounting for >1.2 million users who require treatment each year. Current treatments rely on suppressing immediate withdrawal symptoms and replacing illicit drug use with long-acting opiate drugs. However, the mechanisms that lead to preventing opiate dependence are still poorly understood. ...

2017
Yan Sun Linwen Liu Jiajia Feng Weihua Yue Lin Lu Yong Fan Jie Shi

The rs1137070 polymorphism of monoamine oxidase A (MAOA) is associated with alcoholism and smoking behavior. However, the association between rs1137070 and heroin addiction remains unclear. In this study, we examined the allelic distribution of rs1137070 in 1,035 heroin abusers and 2,553 healthy controls and investigated the interactive effects of rs1137070 and heroin addiction on gray matter v...

Journal: :Croatian medical journal 2003
Neda Vidjak

AIM To analyze the success of three different treatment modalities for heroin addiction: methadone therapy, hospital therapy without methadone, and therapeutic community. METHODS Ninety heroin addicts from the city of Split, Croatia, were systematically allocated to three groups, with 30 participants each, according to the addiction treatment modality they underwent or treatment that resulted...

2017
Ruixuan Jiang Inyoung Lee Todd A. Lee A. Simon Pickard

OBJECTIVE Heroin use in the United States has reached epidemic proportions. The objective of this paper is to estimate the annual societal cost of heroin use disorder in the United States in 2015 US dollars. METHODS An analytic model was created that included incarceration and crime; treatment for heroin use disorder; chronic infectious diseases (HIV, Hepatitis B, Hepatitis C, and Tuberculosi...

Journal: :Behavioural pharmacology 2012
Jun-Xu Li Wouter Koek Charles P France

The cannabinoid receptor agonist Δ(9)-tetrahydrocannabinol (THC) enhances the antinociceptive effects of µ-opioid receptor agonists, raising the possibility of using a combination of THC and opioids for treating pain. This study examined the effects of noncontingent and contingent administration of THC on intravenous heroin self-administration in rhesus monkeys. Self-administration of different...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
Z X Xi E A Stein

An emerging hypothesis to explain the mechanism of heroin-induced positive reinforcement states that opiates inhibit gamma-aminobutyric acid (GABA)-ergic interneurons within the mesocorticolimbic dopamine (DA) system to disinhibit DA neurons. In support of this hypothesis, we report that the development of heroin self-administration (SA) behavior in drug-naive rats and the maintenance of SA beh...

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