Enterovirus A71 (EV-A71) causes self-limiting, hand-foot-and-mouth disease (HFMD) that may rarely be complicated by encephalomyelitis. Person-to-person transmission is usually by fecal-oral or oral-oral routes. To study viral replication sites in the oral cavity and other tissues, and to gain further insights into virus shedding and neuropathogenesis, we developed a consistent, orally-infected,...

BACKGROUND The role of cell-surface glycoconjugates in oral mucosal graft-versus-host disease (GVHD) is still unclear, even though molecular changes in the oral epithelium are essential for the pathogenesis of these lesions. In this study, we investigated changes in the binding of mannose (Man)-specific Lens culinaris lectin (LCA) in the oral mucosa of rats with GVHD. METHODS Lewis rat spleen...

In order to reconstruct the mucosal lining of the oral cavity tissue engineered autologous mucosa grafts could be of great benefit. In conventional stagnant cultures cells often tend to dedifferentiate. Perfusion culture has been demonstrated to reestablish differentiation in various epithelial cell types. Thus, in secondary cultures of human oral keratinocytes from ten patients conventional st...

introduction: in orthodontic therapy ,different materials are used and their presence in oral cavity may modify their properties. the purpose of this study was to evaluate the direct and indirect biocompatibility of three orthodontic composite resins on culture of human oral fibroblasts. methods: this was an interventional experimental study. the biocompatibility of three orthodontic composite ...

Oral leukoplakia, oral submucous fibrosis and erythroplakia are 3 major types of oral premalignant lesions. Multiple oral premalignant lesions may possibly develop due to field cancerization, where carcinogenic exposures can cause simultaneous genetic defects to the upper aerodigestive tract epithelium, putting the epithelium at high risk for development of premalignant lesions at different sta...

PURPOSE We investigated the potential of cyclooxygenase (COX)-2 as anappropriate chemopreventive and/or therapeutic target for oral cancer. EXPERIMENTAL DESIGN Immunohistochemical analysis of COX-2 expression was carried out on 37 oral squamous cell carcinomas (OSCCs) and 23 normal oral epithelium samples. We investigated whether the COX-2-selective inhibitor NS398 induced growth inhibition i...

background: the differences between marginal gingiva and interdental papilla may be due to variation in the molecular composition of these two different anatomical structures. the aim of this study was to evaluate the staining intensity of fibronectin in human marginal gingiva and interdental papilla. materials and methods: in a prospective analytical study, 16 healthy subjects needing crown le...

RAM11 is a mouse monoclonal anti-rabbit macrophage antibody recognizing connective tissue and vascular macrophages. Our previous report showed that RAM11 reacted with basal cells of stratified squamous epithelia of rabbit skin, oral mucosa and esophagus. The aim of the present study was to follow the appearance of RAM11 immunoreactivity in basal cells of regenerating oral epithelium in rabbits....