نتایج جستجو برای: human gastric carcinoma

تعداد نتایج: 2023405  

2012
Zhi Liu Mingzhao Xing

BACKGROUND This study was designed to explore the therapeutic potential of suppressing MAP kinase and PI3K/Akt pathways and histone deacetylase (HDAC) to induce the expression of sodium/iodide symporter (NIS) and radioiodine uptake in non-thyroid cancer cells. METHODS We tested the effects of the MEK inhibitor RDEA119, the Akt inhibitor perifosine, and the HDAC inhibitor SAHA on NIS expressio...

Journal: :Indian journal of physiology and pharmacology 2004
R Tandon H D Khanna M Dorababu R K Goel

Oxidative stress is believed to initiate and aggravate many diseases including peptic ulcers and gastric carcinoma. We observed an increase in rat gastric mucosal lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in cold restraint stress-induced gastric ulceration while, in clinical peptic ulceration and gastric carcinoma patients, an increase in se...

2013
Tonje Seim-Wikse Einar Jörundsson Ane Nødtvedt Tom Grotmol Charlotte R Bjornvad Annemarie T Kristensen Ellen Skancke

BACKGROUND Previous research has indicated a breed predisposition to gastric carcinoma in dogs. However, results to date are inconsistent since several studies have failed to prove such a predisposition. Better knowledge of breeds at risk could facilitate early detection of gastric carcinoma in dogs. The aim of the study was to retrospectively investigate the proportion and possible breed predi...

2015
Alexander H. Kim M. Joshua Shellenberger Zong Ming Chen Jinhong Li

BACKGROUND The most common malignancy to cause gastric outlet obstruction is primary gastric adenocarcinoma and it is followed by carcinoma of the pancreas and gallbladder. Herein, we report a case of gastric outlet obstruction secondary to metastatic lobular breast carcinoma. CASE PRESENTATION Fifty-seven year old Caucasian female with recently diagnosed metastatic lobular breast carcinoma t...

Journal: :South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie 2006
D A Stupart E Panieri D M Dent

OBJECTIVE To investigate the utility of gastrojejunostomy for the palliation of gastric outlet obstruction in irresectable or incurable gastric carcinoma. METHODS This is a retrospective review of 67 patients who underwent a gastrojejunostomy for gastric outlet obstruction caused by gastric carcinoma between 1 January 1996 and 31 May 2003. RESULTS There were 19 complications after surgery, ...

2017
Thanesuan Nuanyai Benjamat Chailap Anumart Buakeaw Songchan Puthong

A new clerodane diterpene, Caseargrewiin M (1), and one known compound (2) were isolated from fresh ripe fruits of Casearia grewiifolia. The structures of all isolated compounds were evaluated on the basic 1D (H and C) and 2D NMR (COSY, HSQC, HMBC and NOESY) spectral data. All compounds were examined cytotoxicity with five human cancer cell lines, Hep-G2 (hepatocarcinoma), SW620 (colon adenocar...

2015
Ido Mizrahi Haggi Mazeh Ronit Grinbaum Nahum Beglaibter Michael Wilschanski Vera Pavlov Muchamad Adileh Alexander Stojadinovic Itzhak Avital Ali Osmay Gure David Halle Aviram Nissan

BACKGROUND Long non-coding RNAs (lncRNAs) have been shown to have functional roles in cancer biology and are dys-regulated in many tumors. Colon Cancer Associated Transcript -1 (CCAT1) is a lncRNA, previously shown to be significantly up-regulated in colon cancer. The aim of this study is to determine expression levels of CCAT1 in gastric carcinoma (GC). METHODS Tissue samples were obtained f...

Journal: :Oncology reports 2007
Masaru Saito Manabu Iwadate Masashi Higashimoto Koichiro Ono Yuji Takebayashi Seiichi Takenoshita

Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. PA acts as a second messenger in cell proliferation; therefore PLD is believed to play an important role in carcinogenesis. PLD activity has been reported to be elevated in human breast, gastric, renal cell and colorectal carcinomas, compared with adjacent non-neoplastic ti...

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