Background: Necrotizing enterocolitis (NEC) is a lethal disease affecting newborns with significant morbidity and mortality rates. Moreover, it is the most eminent gastrointestinal threat affecting premature newborns. Unfortunately, early symptoms and signs are usually vague; therefore, there is a special demand for sensitive biomarkers in this regard. This study aimed to investigate the role o...

BACKGROUND & AIMS An increasing number of physicians use repeated measurements of stool calprotectin to monitor intestinal inflammation in patients with inflammatory bowel diseases (IBDs). A lateral flow-based rapid test allows patients to measure their own stool calprotectin values at home. The test comes with a software application (IBDoc; Bühlmann Laboratories AG, Schönenbuch, Switzerland) t...

Background: The infectious nature of severe early-childhood caries (S-ECC) points to the possible participation of immunologic host responses including neutrophils and their antimicrobial products. Objectives: The aim of this study was to determine the neutrophil apoptosis, α-defensins (HNP1-3) and calprotectin levels in the saliva of preschool children and the association with S-ECC. Methods: ...

AIM Due to parental concern regarding the child's bowel habits and the ongoing discussion whether there might be an association between autism and intestinal inflammation, two inflammatory markers were analysed in a group of children with autism. METHODS Twenty-four consecutive children with autism (3-13 years) of unknown aetiology were investigated with respect to faecal calprotectin and rec...

V arious laboratory biomarkers have been studied in inflammatory bowel disease (IBD) as diagnostic aids, indicators of disease activity or severity, and to predict the risk of relapse in those patients in remission. These biomarkers have enormous potential implications for patient management. For example, therapeutic decisions could be directed more appropriately if a marker could reliably dist...

introduction due to limitation of colonoscopy in assessing the entire bowel and patients’ intolerance in inflammatory bowel disease (ibd), in the current study, we aimed to prospectively compare the accuracy of 99m tc(v)-dimercaptosuccinic acid (dmsa) and fecal calprotectin with ileocolonoscopy as new methods for localizing inflammations. methods current prospective study conducted between 2012...

background: the infectious nature of severe early-childhood caries (s-ecc) points to the possible participation of immunologic host responses including neutrophils and their antimicrobial products. objectives: the aim of this study was to determine the neutrophil apoptosis, α-defensins (hnp1-3) and calprotectin levels in the saliva of preschool children and the association with s-ecc. methods: ...

BACKGROUND In children with symptoms suggestive of inflammatory bowel disease (IBD) who present in primary care, the optimal test strategy for identifying those who require specialist care is unclear. We evaluated the following three test strategies to determine which was optimal for referring children with suspected IBD to specialist care: 1) alarm symptoms alone, 2) alarm symptoms plus c-reac...