Sickle cell disease is a genetic disease that increases systemic inflammation as well as the risk of pediatric strokes, but links between sickle-induced inflammation and arterial remodeling are not clear. Cathepsins are powerful elastases and collagenases secreted by endothelial cells and monocyte-derived macrophages in atherosclerosis, but their involvement in sickle cell disease has not been ...

By E. SILvEsTR0NI, M.D. AND I. BIANCO, M.D. S ICKLE CELL ANEMIA is a severe chromsic disease usually confined to the Negro race l ttt occasiotsally foutsd its imidividuals of the white race mostly of Southerti Italians on Greek stock. Clitsically there is chromsic hemolytic amsemia s ’iths crises, osteo-muscular pains, bouts of severe abcbomitsal pain and ulceratiomis of the legs. Hematological...

Sickle cell anaemia (SCA) is characterized with sever anaemia and vasoocclussive episodes. Nitric Oxide (NO) a potential vasodilator, synthesized from various cells including endothelial cell. However SCA is associated with endothelial dysfunction, a measure cognitive factor for pulmonary hypertension (PH) and vasoocclussive crisis. The present study was attempted to evaluate level of serum NO ...

Background: There are many parameters that modulate the severity of sickle cell anemia. Fetal hemoglobin (Hb F) is one of these major variables. However, its effect is clinically inconsistent. We conducted a descriptive study to assess the influence of Hb F on clinical events and hematological variables in patients with sickle cell anemia. Methods: 151 patients with sickle cell anemia with a st...

Dr. A.K. Al-Ali, College of Medicine and Medical Sciences (43), King Faisal University, P.O. Box 2114, Dammam 31451 (Saudi Arabia) It has been reported that sickle cell anemia patients have elevated serum levels of uric acid [1, 2]. This has been ascribed to altered renal function or increased bone marrow activity [3, 4]. The majority of investigations have been carried out on subjects of Afric...

Background. Priapism is a pathological condition of penile erection that persists beyond, or is unrelated to, sexual stimulation. Impotence and infertility are major problems in male sickle cell disease patients, and priapism has been implicated as a cause of impotence and infertility. The aim of this study is to determine priapism prevalence and assess the knowledge of male homozygous male pat...