In this era of evidence based medicine and drug discovery we are fortunate to get new molecules as treatment options but they are under continuous pharmacovigilance.The arrival of the thiazolidione compounds (also known as ‘glitazones’) with the introduction of troglitazone for treatment of type 2 diabetes heralded a new era in the management of type 2 diabetes. For the first time, a class of d...

Owing to their present use as rocket fuels and their pharmacologic activity as central nervous system stimulants, substituted hydrazines and hydrazine derivatives have come into increasing use in recent years. The parent compound hydrazine and the methyl-substituted hydrazines are of potential hazard because of their toxicity, volatility, and explosive nature. Exposure to hydrazine vapor brings...

Medicinal plants play a key role in human health care. Pterocarpus marsupium is one of the plants used in treatment of diabetes mellitus and the present study was aimed to assess hepatoprotective effect of the plant against CCl(4) induced hepatotoxicity. Wistar albino rats were divided into four groups. Group I was normal control group; Group II, the hepatotoxic group was given CCl(4) (2ml/kg b...

Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers. In this study, we developed a serum metabolomic method based on gas chromatography-mass spectrometry (GC-MS) to evaluate the effect of intragastric administration of entinostat on rats. The entinostat group rats were given 12.3, 49 mg/kg of ent...

We studied effect of exogenous ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on serum lipids and proteins in experimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6 g/kg/day) for 28 days. Both preventive and curative options were studied. Percentage increase in body weight was significantl...

The phospholipids content of Cyperus esculentus tubers were identified by both HPTLC and/or HPLC techniques. The identified phospholipid classes were Phosphatidic acids, Phosphatidylinositol, Phosphatidylethanolamines, Phosphatidylcholine, L-α Phosphatidyl DL-glycerol, Cardiolipin, and L-α-Lysophosphatidylcholine. The hydrolysis of total phospholipids showed that four fatty acids were attached ...