We present a case of bronchocentric granulomatosis in a woman with no history of asthma who was colonised with Aspergillus fumigatus. A family history of chronic granulomatous disease prompted further testing that demonstrated severely depressed neutrophil oxidant production and gp91 deficiency compatible with the X linked carrier state of chronic granulomatous disease. Only one report of the a...

An immunocompetent 28-year-old male aquarium store employee presented with 1 month of intermittent epistaxis. A bleeding granulomatous lesion was identified over the right nasal septum ( Figure 1 ). Histopathology from the incisional biopsy revealed granulomatous inflammation with the presence of acid-fast bacilli ( Figure 2 ). Culture of the homogenized specimen on Middlebrook 7H11 agar after ...

Mycobacterial infections of the skin classically cause a granulomatous tissue reaction. We have observed a suppurative pattern of inflammation associated with infections by rapid-growing Mycobacterium species in immunocompromised patients. We report 6 cases in skin and soft tissue with an unusual but consistent lack of a predominance of granulomatous inflammation. Of the 6 cases, 4 had predomin...

This paper presents for the first time documented evidence, clinical details, and photographic illustrations of metipranolol-associated granulomatous anterior uveitis in 26 eyes of 15 patients being treated for glaucoma. There were 56 episodes of granulomatous anterior uveitis, all associated with large (mutton-fat) keratic precipitates, flare, cells, and 'white eyes' (except in seven episodes)...

In schistosomiasis japonicum, the major pathologic lesion is the granulomatous inflammation that occurs around parasite eggs trapped in the liver. The size of these granulomas and their major sequela, a rise in portal pressure, both peak between 8 and 10 weeks after infection and then spontaneously decrease. We have shown that the adoptive transfer of the serum, but not lymphoid cells, of 30-we...

Granulomatous inflammation is considered to be an immune mechanism against infections or certain non-neoplastic conditions. Rarely granuloma formation may be noted in neoplastic disorders also. However a granulomatous response in the lymph nodes draining cancers is unusual. Such granulomas may sometimes show tumour cells in their centre. The exact cause of this phenomenon is not known but an im...

Pneumocystis carinii pneumonia is a frequent manifestation of the acquired immune deficiency syndrome (AIDS). It usually presents radiologically as diffuse bilateral infiltrates and histologically as a foamy, eosinophilic intra-alveolar exudate containing the organisms' cysts. We recently studied two rare cases of P carinii pneumonia presenting as pulmonary nodules on chest x-ray films in two p...

IntRoductIon Leprosy caused by Mycobacterium leprae (M. leprae), is a chronic granulomatous disease affecting the skin and peripheral nervous system, which is transmitted through direct contact with nontreated or inadequate treatment patients.[1] Diagnosis of leprosy depends on the clinical signs and symptoms and slit skin smear positivity. However, it’s sometimes similar with other granulomato...

INTRODUCTION Actinic granuloma is a granulomatous reaction resulting from longstanding sun damage to the dermis. It is described clinically by the appearance of flesh-colored or pink papules, which classically coalesce into annular lesions. Diagnosis is typically made histopathologically, with findings of granulomatous inflammation associated with elastophagocytosis andmacrophage ingestion of e...

Sir, Hyaluronic acid, one of the components of the extracellular matrix of dermis and other tissues, has natural hydrating functions with an ability to bind a large volume of water. It can be modified to form an insoluble, cross-linked, high viscosity gel whose dermal injection is suitable for the correction of soft tissue defects and the improvement of facial contouring. Dermal injection is ge...