Although the bacterium Symbiobacterium thermophilum has a genome with a high guanine-cytosine (GC) content (69%), it belongs to a low GC content bacterial group. We detected only 18 low GC content regions with 5 or more consecutive genes whose GC contents were below 65% in the genome of this organism. S. thermophilum has 66 transposase genes, which are markers of transposable genetic elements, ...

Background: In forensic medicine, predicting the age of a victim or suspect can be clue to solving crime. Epigenetics has recently played vital role in prediction medicine. Cytosine methylation at cytosine and guanine separated by phosphate (CpG) sites is well recognized as novel epigenetic marker for estimation. This study aimed summarize information obtained from previous studies determine ev...

To date, the field of ancient DNA has relied almost exclusively on mitochondrial DNA (mtDNA) sequences. However, a number of recent studies have reported the successful recovery of ancient nuclear DNA (nuDNA) sequences, thereby allowing the characterization of genetic loci directly involved in phenotypic traits of extinct taxa. It is well documented that postmortem damage in ancient mtDNA can l...

Electron attachment to double-stranded cytosine-rich DNA, dCpdC:dGpdG, has been studied by density functional theory. This system represents a minimal descriptive unit of a cytosine-rich double-stranded DNA helix. A significant electron affinity for the formation of a cytosine-centered radical anion is revealed to be about 2.2 eV. The excess electron may reside on the nucleobase at the 5' posit...

Synthetic homopolyribonucleotides poly(A), poly(U), poly(C), and poly(G), poly(A, G, U), apurinic acid and native and denatured DNA from calf thymus were analyzed by means of cyclic voltammetry (CV) using a hanging mercury drop electrode. It was shown that guanine containing polynucleotides, i.e. poly(G), poly(A, G, U) and DNA yield an anodic peak of guanine in the vicinity of a potential of -0...

Abstract One of the most important topics in molecular biology is genetic stability DNA. threat to this proton transfer along hydrogen bonds DNA that could lead tautomerisation, hence creating point mutations. We present a theoretical analysis between Guanine-Cytosine (G-C) nucleotide, which includes an accurate model structure base pairs, quantum dynamics bond proton, and influence decoherent ...