نتایج جستجو برای: guanidine

تعداد نتایج: 3719  

Journal: :Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2013
Muhammad Jamil Ataf Ali Altaf Amin Badshah Shafiqullah Ibrar Ahmad Muhammad Zubair Saqib Kemal Muhammad Irshad Ali

A novel class of azo-guanidine compounds is introduced in this article. The novel compound 2-(2-hydroxyphenyl)-1-(phenylamino)-3-(phenylimino)guanidine (AG) was synthesized and well characterized by using different analytical instrumental techniques like elemental analysis, FTIR, (1)H and (13)C NMR, UV-Visible spectroscopy and cyclic voltammetry. The new compound was found interacting with DNA ...

2010
Keisuke Iida Masayuki Tera Takatsugu Hirokawa Kazuo Shin-ya Kazuo Nagasawa

Structure-activity relationship studies were carried out on macrocyclic hexaoxazole (6OTD) dimers, whose core structure stabilizes telomeric G-quadruplexes (G4). Two new 6OTD dimers having side chain amine and guanidine functional groups were synthesized and evaluated for their stabilizing ability against a telomeric G4 DNA sequence. The results show that the 6OTD dimers interact with the DNA t...

Journal: :Organic & biomolecular chemistry 2013
Yoshihiro Sohtome Takahisa Yamaguchi Shinji Tanaka Kazuo Nagasawa

Here we describe our studies on solvent-dependent enantiodivergent Mannich-type reactions utilizing conformationally flexible guanidine/bisthiourea organocatalyst (S,S)-1. Our mechanistic investigations revealed that the stereo-determining steps in both the (R)- and (S)-selective Mannich-type reactions are governed by the cooperative effect of guanidine and thiourea in the inherently monomeric ...

2005
Kichul Jung Jaebok Park Pil-Jae Maeng Hackjin Kim

Fluorescence of green fluorescent protein mutant, 2-5 GFP is observed during denaturation by guanidine. The fluorescence intensity decreases exponentially but the fluorescence lifetime does not change during denaturation. The fluorescence lifetime of the denatured protein is shorter than that of native form. As the protein structure is modified by guanidine, solvent water molecules penetrate in...

Journal: :Chemical & pharmaceutical bulletin 2013
Venkata Ramana Katla Rasheed Syed Chandra Sekhar Kuruva Hema Kumar Kuntrapakam Naga Raju Chamarthi

A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide to afford the corresponding cyanamine (4), which was subsequently reacted with different heterocyclic amines to form th...

Journal: :Macromolecular Rapid Communications 2022

Back Cover: In article 2200377, Cyrille Boyer and co-workers show the antimicrobial polymers as a promising approach to combat multidrugresistant pathogens. A library of 31 amphiphilic ternary containing different cationic groups, including primary amine, guanidine, sulfonium is prepared investigate impact groups on activity cytotoxicity against mammalian cells.

Journal: :Journal of virology 1984
K Anderson-Sillman S Bartal D R Tershak

Eighteen spontaneous, guanidine-resistant mutants of poliovirus were obtained by plaque selection. Isoelectric focusing demonstrated charge changes in a 37-kilodalton protein, pX, among three of the mutants. The precursor of pX, NCVP5b , also exhibited charge changes among the three mutants. pX of 12 mutants was also examined by peptide mapping with Staphylococcus aureus V8 protease. Nine of th...

2013
Adriana Huerta-Viga Sander Woutersen

Guanidinium (Gdm+) is a widely used denaturant, but it is still largely unknown how it operates at the molecular level. In particular, the effect of guanidinium on the different types of secondary structure motifs of proteins is at present not clear. Here, we use two-dimensional infrared spectroscopy (2D-IR) to investigate changes in the secondary structure of two proteins with mainly α-helical...

Journal: :Journal of the American Chemical Society 2005
Terra B Potocky Anant K Menon Samuel H Gellman

We have used our ability to control beta-peptide secondary structure in order to explore the effects of conformational stability and geometry of guanidinium display on cell entry. Both of these factors affect the rate and relative amount of beta-peptide accumulation in the cytoplasm and nucleus of live HeLa cells. These beta-peptides do not show significant differences in cell surface binding, ...

Journal: :Chemical communications 2008
Claas H Hövelmann Jan Streuff Lydia Brelot Kilian Muñiz

Palladium catalysed intramolecular guanidine transfer to alkenes can be accomplished with copper chloride as the oxidant to give bicyclic guanidines with complete selectivity and in high yields.

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