The objective of this study was to determine the optimal conditions under which to assess glucose tolerance in chow- and high-fat-fed C57BL/6J mice. Mice were fed either chow or high-fat diet for 8 wk. Variables tested were fasting duration (0-, 3-, 6-, and 24-h and overnight fasting), route of administration (intraperitoneal vs. oral) load of glucose given (2, 1, or 0.5 g/kg and fixed 50-mg do...

The prevalence of diabetes is increasing globally and the total number of people with this condition is projected to rise from 171 million in 2000 to 366 million in 2030 (Wild et al, 2004). India is no exception, with projected rates of 79.4 million in 2030—a 151% increase from 31.7 million in 2000 (Wild et al, 2004). The increased prevalence is attributed to the aging population structure, urb...

OBJECTIVE Muscle carnosine and its methylated form anserine are histidine-containing dipeptides. Both dipeptides have the ability to quench reactive carbonyl species and previous studies have shown that endogenous tissue levels are decreased in chronic diseases, such as diabetes. DESIGN AND METHODS Rodent study: Skeletal muscles of rats and mice were collected from 4 different diet-interventi...

Glucose tolerance test i弓 veryuseful in better understanding the stage of the regenerating process in the remnant liver during the early postoperative period after major hepatic resection. In clinical cases, glucose tolerance test could provide at least some prognostic information concerning operative risk, late survival and the likelyhood of early postoperative liver failure in hepatectorr山edp...

Over the years, what started as a screening to determine which pregnant women were at risk of developing diabetes later in life has changed progressively into a screening for diabetes during pregnancy. From only screening women with risk factors, the medical community has moved to a universal screening for glucose intolerance during pregnancy. Recently, the push has been to expand this screenin...

Lipid infusions may affect glucose tolerance by effects on glucose production or utilization. We performed double-labeled oral glucose tolerance tests with and without a lipid infusion in eight normal subjects. During the lipid infusion, plasma glucose and insulin levels were higher, showing some insulin resistance. The increased glucose level was due to a higher total glucose appearance rate, ...

The HMG box transcription factor Sox9 plays a critical role in progenitor cell expansion during pancreas organogenesis and is required for proper endocrine cell development in the embryo. Based on in vitro studies it has been suggested that Sox9 controls expression of a network of important developmental regulators, including Tcf2/MODY5, Hnf6, and Foxa2, in pancreatic progenitor cells. Here, we...

OBJECTIVE The purpose of this study was to test the hypothesis that any degree of abnormal glucose homeostasis detected on antepartum screening for gestational diabetes mellitus (GDM) should be associated with an increased risk of postpartum pre-diabetes or diabetes. RESEARCH DESIGN AND METHODS In this prospective cohort study, 487 women underwent 1) antepartum GDM screening by a glucose chal...