Long-term exposure to intermittent hypoxia and sleep fragmentation introduced by recurring obstructive sleep apnea (OSA) has been linked to subsequent cardiovascular disease and Type 2 diabetes. The underlying mechanisms remain unclear, but impairment of the normal interactions among the systems that regulate autonomic and metabolic function is likely involved. We have extended an existing inte...

Proper interpretation of forensic measurements can be critical to the administration of justice. Breath alcohol testing is commonly relied upon to measure the concentration of alcohol in breath or, indirectly, in blood. The concentration sought constitutes the "quantity intended to be measured," referred to as the measurand. Although breath tests always probe the same physical quantity, their m...

CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Correspondence: Kok-Ann Gwee, MD Gleneagles Hospital Annexe Block 05-37, 6A Napier Road...

For determination of breath-alcohol concentration (BrAC) the examined subject has to perform a breath test with forced expiration. During this test essential physical quantities change continuously. Ethanol concentration, breath temperature, and breath flow are such important quantities. Significant results can only be obtained if concentration (BrAC) and temperature have reached final values a...

The alcohol breath test (ABT) is evaluated for variability in response to changes in physiological parameters. The ABT was originally developed in the 1950s, at a time when understanding of pulmonary physiology was quite limited. Over the past decade, physiological studies have shown that alcohol is exchanged entirely within the conducting airways via diffusion from the bronchial circulation. T...