Background :Diabetes is one of the most prevalent disease in Indian subcontinent . periodontitis is a know as the sixth complication of diabetes mellitus . Periodontist thus are at a crucial position to examine gingival crevicular blood to screening for diabetes during there routine clinical procedures. Present study focuses on relevance of using gingival crevicular blood as a screening tool to...

OBJECTIVES This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS The study included 30 subjects divided into 2 groups: 20 CP patients and 10 periodontally healthy subjects. Plaque index, gingival index, pocket depth, and c...

Aim To study cytokine profiles and intra-individual correlations in crevicular fluid samples at periodontitis, peri-implantitis, healthy sites. Materials methods Samples from gingival (GCF) peri-implant (PICF) were collected diseased sites patients who had dental implants for a minimum of 10 years. Cytokine levels analyzed using the Bio-Plex Pro Human inflammation kit, which included biomarkers...

Stress is found to be a predictive factor of periodontal disease. Among proposed mechanisms that mediate possible association between psychosocial factors and periodontitis status, immunological pathways are of great importance. Depressed immune responsiveness, as a result of physical or mental stress, influences stress-released hormones (gluco corticoids), which are present in the gingival cre...

Researchers involved in the delivery of periodontal therapy are currently investigating the possible use of oral fluids in the diagnosis of oral diseases and drug development. Substantial improvements have been made in the understanding of the mediators implicated on the initiation, pathogenesis, and progression of periodontitis. This review will analyze the mechanisms involved in the breakdown...

Saliva started for been less studied than other body fluids, but in the last years it has being receiving an increased attention. Until now, more than 2000 different proteins and peptides have been identified in whole saliva and salivary glandular secretions [1]. From these, more than 90% derive from the secretion of the three pairs of “major” salivary glands (parotid, submandibular and subling...

Objectives This study aimed to assess and compare the microleakage of two bulk fill and one conventional composite in class II restorations of primary posterior teeth. Materials and Methods This in vitro, experimental study was conducted on 60 primary mandibular second molars, which were randomly divided into three groups. Standard class II cavities were prepared in teeth and restored with 3M...

BACKGROUND We previously demonstrated that 25-hydroxyvitamin D(3) concentrations in gingival crevicular fluid are 300 times higher than those in the plasma of patients with aggressive periodontitis. Here we explored whether 25-hydroxyvitamin D(3) can be synthesized by periodontal soft tissue cells. We also investigated which of the two main kinds of hydroxylases, CYP27A1 and CYP2R1, is the key ...