BACKGROUND The interconnected Ras/ERK and PI3K/AKT pathways play a central role in colorectal tumorigenesis, and they are targets for elucidating mechanisms involved in attempts to induce colon cancer cell death. Both ginger (Zingiber officinale) and honey have been shown to exhibit anti-tumor and anti-inflammation properties against many types of cancer, including colorectal cancer. However, t...

Diabetic nephropathy is a progressive kidney disease and is characterized by diffuse glomerulosclerosis and nephrotic syndrome. Diabetic nephropathy is due to an-giopathy of capillaries in the kidney glomeruli and is a prime indication for dialysis. It might be seen in patients with diabetes mellitus (DM) after about five years in type 1 diabetes and affects 25% to 35% of patients under the age...

Organophosphorus (OP) compounds commonly used as pesticides in agriculture cause serious health problems to living beings. The present study enumerates the ameliorating effect of ginger extract (GE) against phosphamidon (PHO, an organophosphorus insecticide) induced hepatotoxicity. GE was prepared from dried ginger and characterized for compound profile and antioxidant activity. Eight groups of...

Background: Cyclophosphamide as an alkalizing and cytotoxic agent contributes in treatment of different kinds of cancer. It can pass the blood-brain barrier. Linking two strains of DNA in cell nucleus and breaking the inner and outer strain linkages and inhibiting RNA synthesis and as a consequence, inhibiting protein synthesis, cyclophosphamide demonstrates severe pharmacological side effects ...

Mancozeb is an ethylene-bis-dithiocarbamate (EBDC) fungicide. It is used in a wide range to control several of fungal diseases in field crops and fruits. Administration of mancozeb at a dose level of 1/10 LD50 3 times / week for six weeks induced marked histological and histochemical changes in thyroid gland of albino rat. The histological changes included dilation and congestion in blood vesse...

Introduction: The ginger rhizome has been widely used in traditional medicine for treatment of gastrointestinal diseases. In the present study the effect of ginger alcoholic extract on mechanical activity of isolated jejunum of male rats and also its interaction with cholinergic, adrenergic and Nitrergic systems were investigated. Methods: Seven adult male Wistar rats were anesthetized by et...

Plant extracts are very cost effective and eco-friendly and thus can be used as an economic and efficient alternative for the large-scale synthesis of nanoparticles. We report on the use of ginger extract for the biosynthesis of silver nanoparticles. Bioactive silver nanoparticle synthesis was byreacting the ginger extract with aqueous silver nitrate solution at room temperature (27±2 C) and at...

Introduction: Ginger has shown anti-nociceptive effects. Here we investigated the possible involvement of GABAA receptors in anti-nociceptive effect of ginger using muscimol (GABAA agonist) and picrotoxin (GABAA antagonist) in rats that received ginger. The pain sensitivity was evaluated by formalin test. Methods: Thirty-five male Sprague-Dawley rats were randomly divided into 7 groups (n=5): s...

background: inflammation and pain induced by delayed onset muscle soreness (doms) as a result of eccentric exercise (ee) or unaccustomed activity cause some difficulties in exercise for athletes. the purpose of this study was to survey the effect of ginger extract on biochemical and functional symptom of delayed onset muscle soreness.   methods : in a quasi-experimental study, 36 healthy female...