Serum gamma-glutamyltransferase (GGT) and alkaline phosphatase (AP) were assayed in 98 consecutive patients with rheumatoid arthritis. Twenty-three patients had increased GGT activities and 45 an increased AP activity. Twelve patients showed an increase in both enzyme activities and AP isoenzyme studies were performed on seven of this group. In three subjects an increase in the bone isoenzyme w...

Since early after the introduction of serum gamma-glutamyltransferase (GGT) in clinical practice as a reliable and widely employed laboratory test, epidemiological and prospective studies have repeatedly shown that this activity possesses a prognostic value for morbidity and mortality. The association is independent of possibly concomitant conditions of liver disease, and notably, a significant...

Dear Editor: We would like to call the attention of the readers on a biochemical aspect generating occasional disputes in studies concerned with oxidative stress-related apoptosis. The paper recently published in this journal by Moon et al. (2012) documents that the mutation of K-RAS in prostate epithelial cells causes the activation of the ERK signalling pathway and an increased expression of ...

Objectives: In this present study the hepatoprotective effect of an optimized herbal formula (HF) was appraised against paracetamol induced liver damage in rats. Methods: In vitro antioxidant activity HF evaluated by ABTS radical scavenging assay. The (100, 200 and 400 mg/kg b.w) assessed Serum enzymatic levels serum glu...

Background & AimsGamma-glutamyltransferase (GGT) is a serum marker of cholestasis. We investigated whether level GGT prognostic for patients with primary biliary cholangitis (PBC).MethodsWe analyzed data from PBC the Global Study Group, comprising 14 centers in Europe and North America. obtained measurements at baseline time points after treatment. used Cox model hazard ratios to evaluate assoc...

Background and Aims: Post exercise proteinuria and increased urinary Gamma-Glutamyl transferase (GGT) levels can be indicative of exercise-induced renal damage. The aim of this investigation was to study the effect of one session of intensive training on renal tubular injury markers and compare their values to those 6 hours after training, for evaluating tubular damage after intensive ...

Results: Compared with the other groups, oligospermic group had the highest proportion of specimens with abnormal liquefaction (26.0%) and leukocyte counts (32.0%). Both oligospermic and asthenospermic groups had comparable sperm motility, which was lower than that in normospermia (p < 0.05). The mean levels of γ-GT and Mg in oligospermia were significantly lower than that in all other groups. ...

BACKGROUND Gamma-glutamyltransferase (GGT) is a biomarker of liver injury. GGT has also been reported to be a marker of oxidative stress and a predictor of mortality in the general population. Hemodialysis (HD) patients suffer from oxidative stress. The aim of our study was to investigate the relationship between serum GGT levels and clinical outcomes in HD patients. METHODS A total of 1,634 ...

Gamma-glutamyltransferase (GGT) is an established marker for proliferative/apoptotic balance and has been associated with cancer risk and prognosis. The aim of this study was to evaluate the value of pre-treatment GGT serum levels as prognostic biomarker in patients with primary uterine leiomyosarcoma (ULMS). Data of women with ULMS were extracted from a multi-center database. Pre-treatment GGT...

BACKGROUND Serum gamma-glutamyltransferase (GGT) has been introduced as a predictive factor for cardiovascular disease. In this study, we investigated the association of serum GGT and premature coronary artery disease (CAD) in candidates for coronary angiography. METHODS In this cross-sectional study, we enrolled male subjects aged ≤45 years and female subjects ≤55 years who were candidates f...