نتایج جستجو برای: fgfr

تعداد نتایج: 1529  

Journal: :Journal of hematology & oncology 2015
Alejo Rodriguez-Vida Matilde Saggese Simon Hughes Sarah Rudman Simon Chowdhury Neil R Smith Peter Lawrence Claire Rooney Brian Dougherty Donal Landers Elaine Kilgour Hendrik-Tobias Arkenau

BACKGROUND Urothelial cancers (UC) are the fourth most common tumours worldwide after prostate (or breast), lung and colorectal cancer. Despite recent improvements in their management, UC remain an aggressive disease associated with a poor outcome. Following disease progression on first-line platinum-based chemotherapy, very few effective treatment options are available and none of them have sh...

2016
Jennifer J. Wheler Johnique T. Atkins Filip Janku Stacy L. Moulder Philip J. Stephens Roman Yelensky Vicente Valero Vincent Miller Razelle Kurzrock Funda Meric-Bernstam

There is limited data on co-expression of FGFR/FGR amplifications and PI3K/ AKT/mTOR alterations in breast cancer. Tumors from patients with metastatic breast cancer referred to our Phase I Program were analyzed by next generation sequencing (NGS). Genomic libraries were selected for all exons of 236 (or 182) cancer-related genes sequenced to average depth of >500× in a CLIA laboratory (Foundat...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Murry W Wynes Trista K Hinz Dexiang Gao Michael Martini Lindsay A Marek Kathryn E Ware Michael G Edwards Diana Böhm Sven Perner Barbara A Helfrich Rafal Dziadziuszko Jacek Jassem Szymon Wojtylak Aleksandra Sejda Joseph M Gozgit Paul A Bunn D Ross Camidge Aik-Choon Tan Fred R Hirsch Lynn E Heasley

PURPOSE FGFR1 gene copy number (GCN) is being evaluated as a biomarker for FGFR tyrosine kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The exclusive use of FGFR1 GCN for predicting FGFR TKI sensitivity assumes increased GCN is the only mechanism for biologically relevant increases in FGFR1 signaling. Herein, we tested whether FGFR1 mRNA and protein expression may serve as...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
R L Panek G H Lu T K Dahring B L Batley C Connolly J M Hamby K J Brown

Through direct synthetic efforts, we discovered a small molecule that is a nanomolar inhibitor of the human fibroblast growth factor-1 receptor (FGFR) tyrosine kinase. PD 166866, a member of a new structural class of tyrosine kinase inhibitors, the 6-aryl-pyrido[2,3-d]pyrimidines, was identified by screening a compound library with assays that measure protein tyrosine kinase activity. PD 166866...

Journal: :Cardiovascular research 2008
Masahiro Murakami Arye Elfenbein Michael Simons

Whereas fibroblast growth factors (FGFs) classically transmit their signals via high-affinity tyrosine kinase receptors (FGFR1-4), recent evidence strongly implicates non-tyrosine kinase receptors (NTKR) or cell-surface FGFR-interacting proteins as important players in FGF signalling. Although NTKR have lower affinity for FGFs in comparison with cognate tyrosine kinase receptors, because of the...

2014
Shengqiang Li Zi-Jian Lan Xian Li Jing Lin Zhenmin Lei

BACKGROUND Fibroblast growth factor (FGF) signaling is thought to play diverse roles in the male reproductive system. However, its role in testicular cells for spermatogenesis and fertility remains unclear. METHODS In this study, the expression and localization of Fgfr 1 (FGF Receptor) and Fgfr 2 in the postnatal mouse testes were examined by RT-PCR, Western blotting and immunohistochemistry....

Journal: :Chemistry & Biology 2014

Journal: :Chemistry & biology 2014
Kai Zhang Bianxiao Cui

In this issue of Chemistry & Biology, Kim and colleagues describe their work on optogenetic control of fibroblast growth factor receptor (FGFR) signaling. By engineering a chimeric receptor, the authors demonstrate that FGFR intracellular signaling can be controlled in space and time by blue light.

Journal: :Development 2005
Tinya C Fleming Fred W Wolf Gian Garriga

Although many molecules are necessary for neuronal cell migrations in C. elegans, no guidance cues are known to be essential for any of these cells to migrate along the anteroposterior (AP) axis. We demonstrate that the fibroblast growth factor (FGF) EGL-17, an attractant for the migrating sex myoblasts (SMs), repels the CANs, a pair of neurons that migrate posteriorly from the head to the cent...

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