background: chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. in this study, the gene expression profile of some key chemokine receptors involved in metastasis has been investigated in esophageal and breast cancer cell lines.   methods: in a descriptive study, gene expression profile of ccr1, ccr6, ccr7, ccr9, cxcr1, ...

background: in northeastern iran there is an area of high incidence of esophageal cancer which is populated by residents of turkmen ancestry. several environmental risk factors for esophageal cancer have been proposed, but the roles of familial and genetic factors have not been studied extensively in the turkmen population. materials and methods: we evaluated the importance of familial risk fac...

leiomyoma is a rare esophageal tumor that constitutes less than 1% of esophageal malignancies. it should be removed when diagnosed even if asymptomatic. this study presents two cases of esophageal leiomyoma in 38 and 62 years old men who presented with dysphagia and evaluated for diagnosis and location of related tumors. patients were clinically examined and upper gastrointestinal endoscopy, ch...

Zosteriform metastasis is a rare clinical distribution from spreading neoplasms of every organ to the skin. Tumors most often arise from a n internal o r hematologic malignancy. W e report a 69-year-old man, a known case of malignant melanoma of the left heel. In this case, multiple red-brown metastatic nodules appeared four months after diagnosis. Distribution of metastatic lesions resemb...

conclusions elective gastric pull up can be performed for children who are not above 10 kg. in such settings, the risk of respiratory infections and other complications would be significantly reduced because of shorter duration of intubation. results the mean age was 5 ± 2 years in patients who were above 10 kg and 3 ± 1 years in those less than 10 kg. patients who were less than 10 kg had shor...

PURPOSE The case reports presented here were compiled to demonstrate the potential for improved diagnosis and monitoring of disease progress of intraocular lesions using ultrahigh-field magnetic resonance microscopy (MRM) at 7.1 Tesla. METHODS High-resolution ex vivo ocular magnetic resonance (MR) images were acquired on an ultrahigh-field MR system (7.1 Tesla, ClinScan, Bruker BioScan, Germa...

BACKGROUND Oncogenic BRAF mutations have been found in diverse malignancies and activate RAF/MEK/ERK signaling, a critical pathway of tumorigenesis. We examined the clinical characteristics and outcomes of patients with mutant (mut) BRAF advanced cancer referred to phase 1 clinic. METHODS We reviewed the records of 80 consecutive patients with mutBRAF advanced malignancies and 149 with wild-t...

A 63-year-oldwomanwas referred to our hospital for further investigation of a gastric mucosal abnormality in an upper gastrointestinal series. Esophagogastroduodenoscopy (EGD) demonstrated two areas of flat, widespread blackish pigmentation situated 30 to 33cm, and 34 to 38cm from the incisor teeth (●" Fig.1), and no gastric mucosal abnormality. Distinguishing malignant melanoma from diffuse me...

purpose: to report a rare malignant melanoma with chalazion-like presentation.  case report: a 36-year old woman with a chalazion-like mass in the left upper lid, having been resected twice, was referred to our center for the management of recurrence. the total resection of the suspicious area was done. histopathologic examination confirmed the diagnosis of malignant melanoma. the appropriate r...

Esophageal cancer is a lethal disease with poor survival rate. It is necessary to determine the extension, and the stage of the tumor to predict the outcome of patients. Of the two common pathologic types, squamous cell carcinoma is still the most common form, and adenocarcinoma is the leading one. Early diagnosis and radical treatment of esophageal cancer, regardless of tumor spreading, increa...