Objective(s) The aim of this study was to investigate glycoconjugates distribution patterns as well as their changes during the course of pituitary portal vasculogenesis and angiogenesis. Materials and Methods Formalin fixed paraffin sections of 10 to 20 days of Sprague Dawly rat fetuses were processed for histochemical studies using four different horseradish peroxidase (HRP) conjugated lec...

Background & Aims of the Study: Oxidative stress increases platelet-derived growth factor (PDGF) gene expression in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Oxidative stress generates by dys-regulated redox balance between ROS producing systems and antioxidant systems. Also, Curcumin (Cur) as a main part of tur...

Skin wound healing results in hemostasis, inflammation, proliferation, and remodeling. The early phases require the recruitment of several immune cells from blood. However, role these is not well defined. In addition to monocytes-derived macrophages, known regulate outcome healing, resident macrophages injured skin may play a distinct process. aim was develop 3D autologous model containing endo...

Endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. Endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. Various microRNAs (miRNA) have been discovered in different cellular components of the blood bran barrier (BBB). miRNAs a...

purpose: to assess the short-term effect of mitomycin-c (mmc) 0.02% on endothelial cell density and morphology after photorefractive keratectomy (prk) in patients with moderate myopia. methods: forty-two eyes of 21 participants with moderate myopia (range, -4.0 to -8.0 d) underwent prk with mmc 0.02% for 40 seconds. specular microscopy was performed preoperatively and repeated 6 months after su...

In article number 2007425, Junmin Lee, Ali Khademhosseini, and co-workers present a breakthrough for modeling of non-alcoholic fatty liver disease (NAFLD) based on bioengineered multicellular microtissues liver-on-a-chip system. The consisting four major cell types (primary human hepatocytes, stellate cells, Kupffer endothelial cells) recapitulate the pathogenesis hepatic fibrosis driven by NAF...