Growth plate cartilage is central to the process of bone elongation. Chondrocytes originating within the resting zone of the growth plate proceed through a series of intermediate phenotypes: proliferating, prehypertrophic and hypertrophic, before reaching a terminally differentiated state. Disruption of this chondrocyte maturational sequence causes many skeletal abnormalities in poultry such as...

A study was conducted to evaluate the effects of dietary levels of calcium (Ca), nonphytate P (NPP), phytase (Phy) and 25-hydroxycholecalciferol (25-OH) on live performance and bone development in male chicks fed a corn-based diet. Dietary treatments consisted of a 2×2×4×4 factorial arrangements with two levels of supplemental phytase (0 or 1200 FTU kg ), two levels of 25-OH (0 or 69 μg kg ), f...

A study was conducted to evaluate the effects of dietary levels of calcium, nonphytate P (NPP), phytase and 25-hydroxycholecalciferol (25-OH) on live performance and bone development in male chicks fed a wheat-based diet. Dietary treatments consisted of a 2 x 2 x 4 x 4 factorial arrangements with two levels of supplemental phytase (0 or 1200 FTU/kg), two levels of 25-OH (0 or 69 μg/kg), four le...

Tibial dyschondroplasia (TD) cases has not been reported in Tibetan chickens (TBCs), but it is commonly seen in commercial broilers characterized by lameness. The underlying mechanism remains unclear. Hypoxia-inducible factors (HIFs) are important regulators of cellular adaptation to hypoxic conditions. In this study, we investigated the role of HIF-1α, -2α, and -3α in hypoxia and thiram-induce...

Tibial dyschondroplasia (TD) is one of the most common problems in the poultry industry and leads to lameness by affecting the proximal growth plate of the tibia. However, due to the unique environmental and geographical conditions of Tibet, no case of TD has been reported in Tibetan chickens (TBCs). The present study was designed to investigate the effect of high altitude hypoxia on blood para...

INTRODUCTION Primary synovial osteochondromatosis of the hip is a benign disorder, which is not frequently seen clinically. The characteristic of this disease is proliferation of synovium and formation of loose bodies inside the joint. It is known that only the loose bodies derived from synovium were called synovial osteochondromatosis. Although it can take place in any joint, the knee is most ...

INTRODUCTION Ollier's disease is a rare nonhereditary disorder characterized by multiple enchondromas with a predilection for unilateral distribution. Malignant changes in Ollier's disease may occur in adult patients. Radionuclide bone scanning is one method used to assess lesions depicted on radiographs or magnetic resonance images that are presumed to be enchondromas. Also, a bone scan may gi...

Osteochondroma, also known as osteocartilaginous exostosis or just exostosis, was initially described in 1843 by Reid [1]; it is a common benign tumor of the bone accounting for 10% to 15% of all bone tumors and 20% to 50% of all benign bone tumors [2]. These lesions are the most common benign tumors of the appendicular skeleton, located in the metaphyseal region of long bones, particularly the...

BACKGROUND Ollier's disease is a non-hereditary, benign bone tumor which is usually characterized by presence of multiple radiolucent lesions (enchondromas) in the metaphysis of long bones with unilateral predominance. The disease is a rare clinical entity with 1/100000 occurrence in early childhood. Patients mostly present with multiple hard swellings and deformity of the tubular bones special...

#{149} Be familiar with the radiologic manifestations that allow differentiation of the majority of enchondromas and intramedullary chondrosarcomas affecting the appendicular skeleton. Distinction of enchondroma versus intramedullary chondrosarcoma a!fecting the appendicular skeleton (proximal to the metacarpals and metatarsals) is a frequent diagnostic dilemma. The authors studied a large seri...