article about «emergent» or derived behaviour. His work demonstrated that when verbal humans learned different arbitrary conditional discriminations sharing common elements (e.g., A-B and B-C), they could later relate those stimuli in untrained but predictable ways. Barnes, Hegarty and Smeets (1997) proved that this type of training could produce further outcomes. Participants later exposed to ...

Background: We applied stochastic search variable selection (SSVS), a Bayesian model selection method, to the simulated data of Genetic Analysis Workshop 13. We used SSVS with the revisited Haseman-Elston method to find the markers linked to the loci determining change in cholesterol over time. To study gene-gene interaction (epistasis) and gene-environment interaction, we adopted prior structu...

Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, the standard method for estimating variance components in LMMs-the restricted maximum likelihood estimation method (REML)-suffers from several important drawbacks: REML requires individual-level genotypes and phenotypes from all samples in the study, is computationally slow, and produces ...

It is hard to believe that as recently as a decade ago, some of us were finding it virtually impossible to get an epidemiologic study funded from the National Cancer Institute if it required collection and analysis of DNA. Now, it is virtually impossible to get anything funded if you do not! The rapid transformation of epidemiology into the molecular world has been so swift and dramatic that by...

The purpose of the present study was to assess the prognostic impact of T-cadherin expression in patients with triple-negative breast cancer (TNBC). On the basis of the results of immunohistochemical analysis, 106 patients with operable TNBC were divided into two groups, the T-cadherin-positive group and T-cadherin-negative group. Fisher's exact and χ2 tests were employed to analyze clinical da...

We introduce a liability-threshold mixed linear model (LTMLM) association statistic for case-control studies and show that it has a well-controlled false-positive rate and more power than existing mixed-model methods for diseases with low prevalence. Existing mixed-model methods suffer a loss in power under case-control ascertainment, but no solution has been proposed. Here, we solve this probl...

BACKGROUND Little is known about the genes influencing dietary energy and nutrient intakes, despite evidence that these intakes are influenced by genetic factors. OBJECTIVE We aimed to identify, by using a genome-wide linkage analysis, chromosomal regions harboring genes that affect energy and macronutrient intakes. DESIGN Energy, carbohydrate, lipid, and protein intakes were assessed in 83...

Contributors: SFM is the sole author of this paper. She initiated the research, designed the protocol and the data collection instruments, conducted the in-depth interviews, coded and analysed the qualitative and quantitative data and wrote the paper. Fanny Serani (lecturer at the University of Chile) participated in the piloting of the survey instrument and conducted the postnatal survey inter...

Historically, dwarfism was the major genetic defect in U.S. beef cattle. Aggressive culling and sire testing were used to minimize its prevalence; however, neither of these practices can eliminate a recessive genetic defect. We assembled a 4-generation pedigree to identify the mutation underlying dwarfism in American Angus cattle. An adaptation of the Elston-Steward algorithm was used to overco...