Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly(DL-lactide-co-glycolide) [DexbLG] for antitumor drug delivery. Sorafenib-incorporated nanoparticles were prepared by a nanoprecipitation-dialysis method. Sorafenib-incorporated DexbLG nanoparticles were uniformly distributed in an aqueous solution regardless of the content of sorafenib...

Introduction: The development of ophthalmic formulations able to deliver hydrophilic and hydrophobic drugs the inner structures eye restore preocular tear film has been a leading topic discussion over last few years. In this sense, liposomes represent suitable strategy achieve these objectives in ocular drug delivery.Areas covered: Knowledge different physiological anatomical structures, specia...

Bacterial infections cause 300 million cases of severe illness each year worldwide. Rapidly accelerating drug resistance further exacerbates this threat to human health. While dispersed (planktonic) bacteria represent a therapeutic challenge, bacterial biofilms present major hurdles for both diagnosis and treatment. Nanoparticles have emerged recently as tools for fighting drug-resistant plankt...

which typically has a greater stiffness in tumors than in surrounding normal tissues. Exploiting this difference, Liu et al. engineered mechanoresponsive mesenchymal stem cells to act as vehicles for cancer drug delivery in a mouse model. The engineered stem cells accumulated in tumors, delivering the first half of a two-part cancer therapy: the enzyme cytosine deaminase. Subsequently, the drug...

Drug testing outside the laboratory environment has become widespread and provides presumptive results within minutes of collection of the specimen. This has become particularly useful for testing of urine and oral fluid. Applications include workplaces where drug use has safety implications, drivers of vehicles at the roadside and situations where drug impairment is suspected. The present arti...