Cases of cardiac failure due to deficiency in vitamin BI have been recognized in this country, and although the number of reported cases is small, their recognition is important since treatment by adequate doses of vitamin Bl is rapidly effective, whereas the usual methods of treatment fail. Most cases so far reported occurred in patients drinking too much alcohol and living on an inadequate di...

Feeding of protein deficient diet is known to alter the transmembrane signalling in brain of rat by reducing total protein kinase C (PKC) activity. Phospholipid metabolism regulates the activation of PKC through generation of second messengers and the extent of PKC activation accordingly influences the magnitude of phosphorylation of its endogenous substrate proteins. Thus it was speculated tha...

1. Rachitic bone lesions may be produced in rats by a diet containing an excess of calcium, but deficient in phosphates. 2. Similar lesions follow a diet deficient in calcium, but containing an excess of phosphates. The endochondral lesions, however, are less pronounced. 3. A diet deficient in both calcium and phosphate induces atypical rickets. 4. Inorganic salts other than calcium or phosphat...

1. L-histidine (20 g/kg) added to vitamin B12-deficient and cyanocobalamin-supplemented diets based on soya-bean flour reduced the growth of rats given the vitamin B12-deficient diet but stimulated growth of rats given the cyanocobalamin-supplemented diet. Liver weight (g/kg body-weight)increased, but the protein content of the livers decreased, in rats given histidine supplements. The histidin...

The present study investigated the effect of zinc-deficiency on chromosomal abnormalities and mitotic index, interaction zinc deficiency methotrexate. Therefore, two zinc-deficient zinc-adequate diet received mice groups were constituted. Methotrexate was injected to one groups. There no structural numerical abnonnalities in all However, index significantly lower than other methotrexate adminis...

The erythrocyte antioxidant enzyme levels of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of riboflavin-deficient and Trichinella spiralis-infected rats were investigated. The rats were deprived of riboflavin at the 8th week of the experiment. At that time, the erythrocyte glutathione reductase activity coefficient (EGR AC), as an indicator of riboflavin status, was ...

Background: Dietary iron intake is associated with bone metabolism in human and animals. Previous studies have suggested that iron deficiency diminishes bone formation and causes bone loss in rats, however, the detailed mechanisms remain unclear. To clarify the mechanism of the diminishing bone formation in iron deficiency, we examined the renal 25-hydroxyvitamin D3-1α-hydroxylase (1α-hydroxyla...

Methods: Imaging experiments were performed using 11.7T MRI. 22 male C57BL/6 mice were divided into a control group (n=2) fed normal chow and an experimental group (n=20) fed a methionine-deficient choline-deficient (MCD) diet used to induce steatohepatitis. The experimental diet was continued for a total duration of 81 days and mice were sacrificed intermittently throughout this period for ex ...