A series of trans- or cis-stilbenes have been synthesized in good to excellent yields via a functional group-dependent decarboxylation process from the corresponding 2,3-diaryl acrylic acids in a neutral CuI/1,10-phen/PEG-400 system under microwave conditions. The in situ generation of the recyclable catalytic complex, the use of environmentally benign solvent PEG-400, the operational simplicit...

Fluorinated organic compounds have a long history in medicinal chemistry, and synthetic methods to access target fluorinated compounds are undergoing a revolution. One powerful strategy for the installation of fluorinecontaining functional groups includes decarboxylative reactions. Benefits of decarboxylative approaches potentially include: 1) readily available substrates or reagents 2) mild re...

Somatostatin receptor scintigraphy (SNS) with In-labelled somatostatin receptor analog is a standard procedure for the detection and staging of neuroendocrine tumors (NETs, APUDomas). NETs can be small and situated almost throughout the body. This heterogeneous group of tumors take up amino acids, transform them into biogenic amines (dopamine and serotonin) by decarboxylation, and store the ami...

In this study we demonstrate that molecular fragments, which can be readily coupled via a simple, in situ RO-C═OR bond-forming reaction, can subsequently undergo metal insertion-decarboxylation-recombination to generate Csp(2)-Csp(3) bonds when subjected to metallaphotoredox catalysis. In this embodiment the conversion of a wide variety of mixed anhydrides (formed in situ from carboxylic acids ...

During the growth of Penicillium stipitatum, stipitatonic acid was found to be the major component of the culture medium of young cultures, whereas stipitatic acid predominated in older cultures (3). This finding, and the easy chemical decarboxylation of stipitatonic acid to stipitatic acid in boiling water, suggested that the dicarboxylic acid was the precursor of the monocarboxylic acid. Furt...

Tyrosinase usually catalyses the conversion of monophenols into o-diphenols and the oxidation of diphenols to the corresponding o-quinones. Sugumaran [(1986) Biochemistry 25, 4489-4492] has previously proposed an unusual oxidative decarboxylation of 3,4-dihydroxymandelate catalysed by tyrosinase. Our determination of the intermediates involved in the reaction demonstrated that 3,4-dihydroxybenz...