BACKGROUND Hospitals are advised to measure antibiotic use and monitor its relationship to resistance. The World Health Organization's recommended metric is the defined daily dose (DDD). An alternative measure is the number of days of therapy (DOT). The purpose of this study was to contrast these measures. METHODS We measured the use of 50 antibacterial drugs that were administered to adults ...

The paper presents an initial study on designing a Dynamic Data Driven (DDD) computational environment to enable reliable and efficient determination of Head Related Transfer Functions (HRTF) for patients with reconstructed ears. The determination involves a synthesis of coordinated experiments and large scale, parallel computer simulations. Time limits (one working day), cost of MRI scans, and...

Di-1,1-chlorophenyl-2,2,2-trichloroethane (DDT) and its derivatives di-1,1-chlorophenyl-2,2dichloroethane (DDD), di-1,1-chlorophenyl-2,2-dichloroethene (DDE), and di-1,1-chlorophenyl-2-chloroethene (DDMU) were dechlorinated in heptane solution over a sulphide Ni-Mo/C catalyst in a batch reactor. The process was carried out at 150-260oC and hydrogen pressure of 3 MPa. For DDT, fast elimination o...

The problem of when the k-subdirect sum of a doubly diagonally dominant matrix (DDD matrix) is also a DDD matrix is studied. Some sufficient conditions are given. The same situation is analyzed for diagonally dominant matrices and strictly diagonally dominant matrices. Additionally, some conditions are also derived when card(S)>card(S1) which was not studied by Bru, Pedroche and Szyld [Electron...

Mitotane (DDD) is prescribed in adrenocortical renal carcinoma. Its principal metabolite, dichlorodiphenylethene (DDE), can accumulate fat tissues and from a toxicological point of view, probably more interesting than the other metabolite dichlorodiphenylacetate (DDA). Therapeutic Drug Monitoring (TDM) DDD plasma concentrations required to combine therapeutic efficacy with acceptable toxicity. ...

Elucidation of molecular targets is very important for lead optimization during the drug development process. We describe a direct method to find targets of antitrypanosomal compounds against Trypanosoma brucei using a trypanosome overexpression library. As proof of concept, we treated the library with difluoromethylornithine and DDD85646 and identified their respective targets, ornithine decar...

The aim of the work was to analyze use Transanal Hemorrhoidal Dearterialization (THD) in surgical treatment hemorrhoids various degrees. THD for complicated 514 patients period 2008–2021 analyzed on clinical basis Department Surgery No.3 Bogomolets National Medical University (Ukraine). average age 39.1 years. 159 (30.9%) had grade II hemorrhoid, 299 (58.2%) – III, 56 (10.9%) IV. All manifestat...