Treatment with doxorubicin (Dox) results in serious systemic toxicities that limit effectiveness for cancer treatment and cause long-term health issues for cancer patients. We identified a new DNA aptamer to prostate-specific membrane antigen (PSMA) using fixed sequences to promote Dox binding and developed dimeric aptamer complexes (DACs) for specific delivery of Dox to PSMA(+) cancer cells. D...

This paper presents a technique for improving the SNR and resolution of complex bandpass ∆ΣADCs which are used for wireless communication systems such as cellular phone, wireless LAN and Bluetooth. Oversampling and noise-shaping are used to achieve high accuracy of a ∆ΣAD modulator. However when a multi-bit internal DAC is used inside a modulator, nonlinearities of the DAC are not noise-shaped ...

Despite the popularity of digital devices, real world signals are typically represented by analog signals. Digital control systems process real world analog signals by using an analog-to-digital converter (ADC) to convert analog signals to digital. Conversions back to analog signals are accomplished using a digital-toanalog converter (DAC). Maxim offers a complete line of precision DACs from 8 ...

The performance of traditional continuous-time (CT) delta-sigma analog-to-digital converters (ADCs) is limited by their large sensitivity to feedback pulse-width variations caused by clock jitter in their feedback digital-to-analog converters (DACs). To mitigate that effect, we propose a modified switched-capacitor (SC) feedback DAC technique, with a variable switched series resistor (SR). The ...

This paper presents MOSFET based analog to digital converter which is simple in design, has high resolution, and conversion rate better than dual slope ADC. It has no DAC which will limit the performance, no error in conversion, can operate for wide range of inputs and never become unstable. One of the industrial applications, where the proposed high resolution MOSFET ADC can be used is, for th...

The long links that interconnect networking and computing systems and boards need high throughput to avoid expensive, massively parallel connections. However, long wires suffer signal losses that increase with frequency. Digital communication techniques can compensate for these losses, but require Analog-to-Digital and Digital-to-Analog converters (ADCs and DACs). To understand the application ...

We present a new variable-length encoding scheme for sequences of integers, Directly Addressable Codes (DACs), which enables direct access to any element of the encoded sequence without the need of any sampling method. Our proposal is a kind of implicit data structure that introduces synchronism in the encoded sequence without using asymptotically any extra space. We show some experiments demon...