نتایج جستجو برای: crossover trial

تعداد نتایج: 343534  

Journal: :Journal of Pharmacology and Experimental Therapeutics 2018

2010
Alberto Moraglio

Uniform crossover for binary strings has a natural geometric interpretation that allows us to generalize it rigorously to any search space endowed with a notion of distance and any representation [6]. In this paper, we present an analogous characterization for one-point crossover and explicitly derive formally specific one-point crossovers for a number of well-known representations.

2012
Murray D. Esler Roland E. Schmieder Paul A. Sobotka

Background—Renal sympathetic nerve activation contributes to the pathogenesis of hypertension. Symplicity HTN-2, a multicenter, randomized trial, demonstrated that catheter-based renal denervation produced significant blood pressure lowering in treatment-resistant patients at 6 months after the procedure compared with control, medication-only patients. Longer-term follow-up, including 6-month c...

This study was designed to elucidate the effect of ascorbic acid on salivary total antioxidant capacity in smokers. In this single blind crossover clinical trial, the whole unstimulated saliva of 30 smokers, who were randomly divided into two groups, was collected. In the first phase after the saliva collection, one group of patients took 500 mg of vitamin C powder, for 3 weeks. Then, saliva of...

2017
Kade Birkeland Raj M Khandwalla Ilan Kedan Chrisandra L Shufelt Puja K Mehta Margo B Minissian Janet Wei Eileen M Handberg Louise Ej Thomson Daniel S Berman John W Petersen R David Anderson Galen Cook-Wiens Carl J Pepine C Noel Bairey Merz

BACKGROUND Digital wearable devices provide a "real-world" assessment of physical activity and quantify intervention-related changes in clinical trials. However, the value of digital wearable device-recorded physical activity as a clinical trial outcome is unknown. OBJECTIVE Because late sodium channel inhibition (ranolazine) improves stress laboratory exercise duration among angina patients,...

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