Citation: Pichaud F (2018) PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration. Front. Cell. Neurosci. 12:90. doi: 10.3389/fncel.2018.00090 The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of t...

Direction-of-arrival (DOA) estimation is one of the most demanding tasks for millimeter wave (mmWave) communication massive multiple-input multiple-output (MIMO) systems with hybrid beamforming (HBF) architecture. In this paper, we focus on optimization HBF matrix receiving pilots to enhance DOA performance. Motivated by fact that many existing algorithms can achieve Cram\'{e}r-Rao bound (CRB),...

Including our own observational material and the Hipparcos photometry data, we investigate the radial velocity and brightness of suspected Maia variable stars which are classified also in some examples as peculiar stars, mainly for the existence of periodic variations with time-scales of hours. The results lead to the following conclusions: (1) Short-term radial velocity variations have been un...

BACKGROUND In patients with community-acquired pneumonia (CAP), short-term mortality is largely dependent on pneumonia severity, whereas long-term mortality is considered to depend on comorbidity. However, evidence indicates that severity scores used to assist management decisions at disease onset may also be associated with long-term mortality. Therefore, the objective of the study was to inve...

The CRB proteins CRB1, CRB2 and CRB3 are members of the cell polarity complex Crumbs in mammals that together with Scribble and Par complexes stablish the polarity of a variety of cell types. Although many members of the Crumbs complex proteins are expressed in the retinal pigment epithelium (RPE), and even though the mRNA of CRB2 has been detected in ARPE-19 cells and in the RPE/Choroid, to da...

This paper is concerned with the derivation of new estimators and performance bounds for the problem of timing estimation of (linearly) digitally modulated signals. The conditional maximum likelihood (CML) method is adopted, in contrast to the classical low-SNR unconditional ML (UML) formulation that is systematically applied in the literature for the derivation of non-data-aided (NDA) timing-e...

OBJECTIVE To assess the validity of CRB-65 (Confusion, Respiratory rate >30 breaths/min, BP<90/60 mmHg, age >65 years) as a pneumonia severity index in a Malawian hospital population, and determine whether an alternative score has greater accuracy in this setting. DESIGN Forty three variables were prospectively recorded during the first 48 hours of admission in all patients admitted to Queen ...

Development of epithelial cell polarity is a highly dynamic process, and often established by the sequential recruitment of conserved protein complexes, such as the Par or the Crumbs (Crb) complex. However, detailed insights into the refinement of polarity and the formation of the complexes are still lacking. Here, we established fluorescently tagged Lin7c, a core member of the Crb complex, as ...

BACKGROUND Cell polarity genes including Crumbs (Crb) and Par complexes are essential for controlling photoreceptor morphogenesis. Among the Crb and Par complexes, Bazooka (Baz, Par-3 homolog) acts as a nodal component for other cell polarity proteins. Therefore, finding other genes interacting with Baz will help us to understand the cell polarity genes' role in photoreceptor morphogenesis. M...

We consider the use of an arbitrary planar array for direction-ofarrival (DOA) estimation, with the commonly used Cramér-Rao Bound (CRB) as a performance measure. By taking advantage of the cosine structure of the array Fisher information matrix (FIM), the FIM is reformulated to be completely represented by three parameters which depend on the array geometry, leading to a new FIM expression tha...