Disruptions in the hypothalamic-pituitary-adrenal (HPA) axis are thought to be key neuroendocrine mechanisms involved psychopathology and may have intergenerational impacts. Hair-derived HPA hormones offer a measure of long-term activity that useful assessing maternal infant health. Building on community-based randomized control trial perinatal depression intervention Pakistan, we examine effec...

Approximately 2 x 10(11) viable Pasteurella tularensis cells per ml, contained in suspensions, were killed by exposure to 10(6) r of gamma-radiation. When injected intraperitoneally into mice, the irradiated suspensions initially contained about 10 ld(50) per ml, and immunized mice against challenge with fully virulent strains of P. tularensis. Toxicity and immunizing activity of the suspension...

T H E effect of cortisone on the proliferation of tissues other than mesenchymal has received little attention. Bullough (1952) showed that cortisone had a marked effect on the mitotic activity of the epidermis in mice, and Leroy (1952) showed a similar effect on immature testes of rats, but no effect on mature ones. McColl & Weston (1953) have studied the influence of cortisone on the process ...

BACKGROUND Impairment in 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activity results in inefficient inactivation of cortisol to cortisone, and it can trigger hypertension through activation of the mineralocorticoid receptor. Information about age-related changes in 11β-HSD2 activity and its physiological consequences is scarce. Our aim was to investigate whether 11β-HSD2 activity is age...

The examples of concepts are : (1) Collagen Diseases. Attempts have been made to bring many apparently unconnected diseases under the basic pathology of a morbid state of the connective tissue. All of them have been benefited, permanently or temporarily by cortisone and ACTH. (2) Types of Anaemia. This is the main item under the haemopoietic system which has been reviewed. Davidson's classifica...

The activity of cytoplasmic malate dehydrogenase (EC 1.1.1.27) of livers of young (9-10 weeks) and old (60-70 weeks) rats decreases after adrenalectomy and increases after administration of cortisone to adrenalectomized rats. These changes are significantly lower in old rats. The induction by cortisone is inhibited by actinomycin D. Adrenalectomy decreases and cortisone increases the activity o...

For some time, it has been known that the injection of adrenal cortex extracts or adrenal steroids containing oxygen substitutions at the Cn position augments the excretion of nitrogen in the urine of animals either fasting or feeding normally. Similar injections into adrenalectomized or hypophysectomized animals also raise the fasting nitrogen excretion above normal (l-3). On the contrary, the...

The growth of the uterus in ovariectomized rats treated with estradiol was compared with that of similar animals given both cortisone and estradiol. Examination of histological sections of the uteri of rats treated in these two ways revealed no significant differences in general histological topography or cytology. The results of one of the two experiments performed suggested that cortisone may...

BACKGROUND Alopecia areata of the eyebrows can be difficult to treat. Intralesional triamcinolone or potent topical steroids are considered the mainstay of medical therapy. This case illustrates the results of an experimental hair transplant to the eyebrows following years of modest response to intralesional triamcinolone. OBJECTIVE The aim of this study was to ascertain the benefits of a hai...

The effect of chronic tumor necrosis factor-a (TNF-a) and cortisone treatment on the concentration of translational initiation factor eIF-4E in rat skeletal muscle was evaluated. Crude muscle extracts from control and experimental groups (TNF-a s.c. @ 50 microg/kg body wt each day for 5 days or cortisone s.c. @ 100 mg/kg body wt for 5 days) were used to purify eIF-4E by immunoprecipitation and ...