Methods Myocardial blood flow (MBF) was determined by measuring coronary sinus flow with velocity-encoded cine magnetic resonance imaging at 3 teslas. We measured MBF at baseline and in response to sympathetic stimulation by cold pressor testing (CPT) in 17 healthy volunteers with normal left ventricular function (age 24 ±6 years, BMI=21.1±2.6kg/m2). Efat volume was volumetrically assessed by m...

In vitro and animal studies suggest that oxidative stress is associated with endothelial dysfunction. We tested whether local oxidative stress and nitric oxide (NO) bioavailability in the coronary circulation is associated with coronary endothelial dysfunction in humans. Blood samples were obtained simultaneously from the left main coronary artery and the coronary sinus for measurement of F2-is...

BACKGROUND Measurement of coronary sinus blood flow (CSF) by phase-contrast magnetic resonance (PC-MR) imaging at rest and during hyperemia may allow noninvasive assessment of global coronary hemodynamics. METHODS AND RESULTS Sixteen healthy volunteers (age, 22 to 32 years) were examined with MR and PET in random order within 1 to 2 days. At rest and during hyperemia (dipyridamole 0.56 mg/kg)...

In vitro and animal studies suggest that oxidative stress is associated with endothelial dysfunction. We tested whether local oxidative stress and nitric oxide (NO) bioavailability in the coronary circulation is associated with coronary endothelial dysfunction in humans. Blood samples were obtained simultaneously from the left main coronary artery and the coronary sinus for measurement of F2-is...

(with carbon dioxide) in the aortaa mechanical assistance to the failing ciruclation. Am Heart J 63: 669, 1962 24. Braunwald E, Covell JW, Moroko PR, Ross J: Effects of drugs and of counterpulsation on myocardial oxygen consumption: observations on the ischemic heart. Circulation 40 (suppl IV): IV-220, 1969 25. Powell WJ, Daggett WM, Magro AE, Bianco JA, Buckley MJ, Sanders CA, Kantrowitz AR, A...

This study tested whether alpha-adrenoceptor-mediated coronary vasoconstriction is augmented during exercise in diabetes mellitus. Experiments were conducted in dogs instrumented with catheters in the aorta and coronary sinus and with a flow transducer around the circumflex coronary artery. Diabetes was induced with alloxan monohydrate (n = 8, 40 mg/kg i.v.). Arterial plasma glucose concentrati...

By integrating phasic coronary sinus flow curves in such a way that volume flow during systole plus isometric contraction and that during the remainder of diastole can be compared, the relative contribution of ventricular compression and coronary resistance to mean coronary flow can be assessed. It was found that anoxia, adenylic acid, compression of the aorta or pulmonary artery reduces corona...

I read with interest the article of De Paulis et al. “Coronary flow characteristics after a Bentall procedure with or without sinuses of Valsalva” in the July 2004 issue of the European Journal of Cardiothoracic Surgery [1], which examines the effects of the pseudosinuses of a ‘new conduit’ with pseudosinuses (Gelweave Valsalvae, Terumo Vascutek, Renfrewshire, Scotland, UK) upon coronary blood ...

BACKGROUND The effects of cocaine on the coronary circulation were examined in conscious dogs chronically instrumented to measure arterial and left ventricular pressures, coronary blood flow, and arterial and coronary sinus oxygen content. METHODS AND RESULTS With heart rate held constant, the peak effects of cocaine (1 mg/kg i.v.) occurred within 2 minutes, when mean arterial pressure increa...