The purpose of this study is to investigate the process of corneal wound healing after penetrating injury with the change in optical intensity on anterior segment optical coherence tomography (AS-OCT) and to investigate factors associated with severity of corneal scar. Forty-seven eyes from 47 patients with repaired corneal laceration were included. AS-OCT was performed on 1day, 1week, 1, 3 and...

Objectives: To determine if Thalidomide has a similar effect in an alkali burn model of corneal neovascularization, we evaluated the effect of Thalidomide on corneal angiogenesis after alkali corneal burns in rabbits. Methods: Twelve rabbits received alkali burns to one cornea. Post injury, four rabbits received oral Thalidomide, 200 mg/kg/day and eight rabbits received placebo (powdered sugar)...

CASE REPORT A 74-year-old man developed a partial limbal stem cell deficiency secondary to a chemical injury in the left eye. He was treated with a sectorial conjunctival epitheliectomy and amniotic membrane transplantation. After 3 weeks there was an intact, smooth and stable corneal epithelium. DISCUSSION This case report emphasizes that conjunctival epitheliectomy and amniotic membrane tra...

he focus of this article is a multidisciplinary research program that addresses corneal injury from exposure to infrared laser radiation. Our general methodology combines experimental physical and biological measurements with theoretical analyses to understand corneal damage. Damage thresholds are determined under carefully controlled exposure conditions, and mathematical damage models are deve...

Silicone foam elastomer is used extensively to treat granulating wounds. A case is presented in which the catalyst to the polymer was inadvertently applied to the eye. This produced conjunctival and corneal injury, which was slow to heal and resistant to conventional treatment. This form of injury has not previously been described.

Page 57 § 1.1.2.: it is mentioned that some materials can cause serious corneal injury without appearing to change opacity or permeability immediately (e.g. mustard gas). Is this a specific observation for mustard gas or are other examples (agents) known which can induce damage without changes in opacity and/or permeability? Injury (cell death) without any change in opacity and/or permeability ...

PURPOSE Corneal myofibroblasts differentiated from activated corneal stromal cells are the major cellular sources of extracellular matrix synthesis for the repair of corneal injury. In this study, the effects of histone deacetylase (HDAC) inhibitors on the activation, proliferation, migration and senescence of corneal stromal cells were evaluated. METHODS Primary human and mouse corneal strom...

PURPOSE The healing process of some corneal wounds involves closure by stromal contraction and the renewal of the stratified epithelium. In wound gape injury such stromal contraction occurs with epithelial stratification. In previous in vitro studies of noncontracted and contracted corneal fibroblast-seeded collagen gels (FSCGs) it was shown that initiation of wound contraction by the myofibrob...