نتایج جستجو برای: connexins
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Connexins are protein subunits that constitute the gap junction channel, a dodecameric channel connecting two neighbouring cells formed by two hexameric hemichannels provided by either cell. The gap junction channel permits intercellular communication by allowing the propagation of the action potential and the transfer of small molecules such as cAMP. Six different gap junctional proteins (conn...
Homomeric gap junction channels are composed solely of one connexin type, whereas heterotypic forms contain two homomeric hemichannels but the six identical connexins of each are different from each other. A heteromeric gap junction channel is one that contains different connexins within either or both hemichannels. The existence of heteromeric forms has been suggested, and many cell types are ...
Two gap junction proteins, connexin43 (Cx43) and connexin45 (Cx45), are coexpressed in many cardiac and other cells. Homomeric channels formed by these proteins differ in unitary conductance, permeability, and regulation. We sought to determine the ability of Cx43 and Cx45 to oligomerize with each other to form heteromeric gap junction channels and to determine the functional and regulatory pro...
Gap junctions, formed by the connexin (Cx) protein family, are intercellular channels that permit the cytoplasmic exchange of ions and small metabolites between neighboring cells, a process called gap junction intercellular communication (GJIC). These channels possess unique properties, including distinctive permeabilities for various signaling molecules, which depend on the connexin member(s) ...
OBJECTIVES We investigated the influence of cardiopulmonary bypass on cardiomyocyte gap junctions and connexins. METHODS Samples were collected at intervals during operation from the right atrial appendage in 21 patients (mean [+/- SD] age 55 +/- 21 years). Immunodetection of connexins was conducted by Western blotting and confocal microscopy with parallel electron microscopic examination of ...
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