Carotid-cavernous fistulas (CCFs) are rare, pathologic communications of the carotid artery and the venous plexus of the cavernous sinus. They can develop spontaneously in certain at risk individuals or following traumatic head injury. Typical clinical manifestations include headache, proptosis, orbital pain, and diplopia. We report a case of bilateral carotid-cavernous fistulas associated with...

Hypopituitarism in leukemia is very rare. In addition, central nervous system (cns) relapse and leukemic retinopathy in childhood acute lymphoblastic leukemia (all) have declined with the use of modern systemic chemotherapy that includes cns prophylaxis. Here, we report the case of a 4-year-old girl who received chemotherapy and intrathecal therapy without cns radiation after a diagnosis of B-p...

It has been emphasized by Sheehan (1948) that the criterion for the diagnosis of hypopituitarism is destruction of the anterior pituitary, the most frequent cause being post-partum necrosis. Hypopituitarism in the male is relatively uncommon. Escamilla and Lisser (1942), in a survey of 101 " typical clinical cases with pathological verification," found only 35 in the male. The following case, w...

Beckwith-Wiedemann syndrome (BWS) is caused by dysregulation of imprinted genes on chromosome 11.p15.5. The syndrome includes overgrowth, macroglossia, organomegaly, abdominal wall defects, hypoglycemia, and long-term malignancy risk. No patient who has BWS has been reported with hypopituitarism. We describe a patient who presented at birth with macrosomia, macroglossia, respiratory distress, j...

BACKGROUND Traumatic brain injury (TBI) is a leading cause of secondary hypopituitarism in children and adults, and is responsible for impaired quality of life, disabilities and compromised development. Alterations of pituitary function can occur at any time after the traumatic event, presenting in various ways and evolving during time, so they require appropriate screening for early detection ...

BACKGROUND Agenesis of the internal carotid artery (ICA) is a rare congenital abnormality, sporadically reported to be associated with a combined congenital hypopituitarism. Nevertheless, only a few cases have been extensively described, and none of these have been characterized by an isolated growth hormone (GH) deficiency. CASE PRESENTATION Here, we describe a 17-year old boy referred to ou...

Sheehan’s syndrome is a well-known cause of panhypopituitarism following ischemic damage to the pituitary gland or stalk during peripartum period. Degree of hypopituitarism in Sheehan’s syndrome can vary and due to the slow evolution, the diagnosis can be delayed. Here we report a case presented to us with hyponatremia, 2 years after her complicated delivery, which highlights the importance of ...

There have been in the past decade a growing number of studies relating head trauma to hypopituitarism. This condition may affect the rehabilitation process, and identification of such patients is therefore required. However, the widely different methods used so far for this purpose have provided inconsistent results. The incidence rate of hypopituitarism has probably been overestimated. This r...

A case of hypopituitarism and minimal sellar enlargement was found at hypophysectomy to have a giant cell granuloma of the pituitary. The clinical and histopathological features of this rare entity are reviewed. It is proposed that hypopituitarism which is out of proportion to minimal sellar enlargement may be a suggestive clue to the preoperative diagnosis of giant cell granulous which normall...

Background. It is well acknowledged that glucocorticoid (GC) replacement can unmask diabetes insipidus (DI) in subjects with hypopituitarism. Objective. To increase the awareness and monitoring for transient and symptomatic DI in children with partial hypopituitarism during periods in which increased GC needs are required. Methods/Case. A 2-month-old female infant with septo-optic dysplasia (SO...