the term congenital hypopituitarism defines deficiency of all of the pituitary hormones. hypoglycemia and microphallus (in males) are common findings, and some infants have shown evidence of the neonatal hepatitis syndrome. we report a case of congenital panhypopituitarism with deficiency of six major hormones and association with severe hypoglycemia, impaired liver function tests and congenita...

Dursun F, Gerenli N, Kırmızıbekmez H. Cholestasis and hypercalcemia secondary to panhypopituitarism in a newborn. Turk J Pediatr 2017; 59: 100-103. Cholestatic hepatitis and hypercalcemia are rare features of hypopituitarism in newborns. So diagnosis of hypopituitarism is frequently delayed. The most frequent symptoms of congenital hypopituitarism are hypoglycemia, prolonged jaundince and micro...

We are reporting an infant with persistent abnormal liver function, neonatal jaundice, and intermittent hypoglycemia. Evaluation confirmed congenital hypopituitarism, in the absence of congenital anomalies and midline defect. His jaundice and abnormal liver function improved after treatment with Levothyroxine and hydrocortisone.

Panhypopituitarism occurs as a result of the insufficiency all hormones produced in anterior pituitary gland. Pituitary Stalk Interruption Syndrome (PSIS) is rare congenital syndrome leading to hypopituitarism. The should be evaluated patients with signs and symptoms hormone magnetic resonance imaging performed for etiology. Although PSIS cause hypopituitarism, it must treated replacement insuf...

Congenital hypopituitarism may present with non-specific symptoms, so it is difficult to diagnose in newborn infants. If hypopituitarism cannot be recognized, recurrent hypoglycemia can occur, leading to permanent brain damage. At 14 hours of age, a 2.9 kg, female infant, born at 35 weeks of gestation, presented with respiratory distress caused by hypoglycemia. She had no risk factor to develop...

BACKGROUND Childhood hypopituitarism may be present at birth or may be acquired. Early diagnosis and treatment promote the best possible outcomes. METHODS The anatomy, etiologies, clinical presentation, diagnostic testing strategies, and current treatments relevant to childhood hypopituitarism are reviewed. RESULTS Children with congenital hypopituitarism may present with life-threatening h...

There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. To present data regarding the etiology of hypopituitarism collected in a tertiary center over the last decade. This is a cross-sectional database study. Patients and Methods. We included 512 patients (pts) wi...

The clinical phenotype of congenital pituitary hormone deficiency is variable and can be associated with a number of structural abnormalities of the central nervous system. We report three Japanese patients with congenital pituitary hormone deficiency and ophthalmological anomalies. Two of the patients initially showed strabismus and unilateral optic nerve hypoplasia. Thereafter, growth failure...

BACKGROUND Extra-pituitary birth defect (EPBD) in children with congenital hypopituitarism is largely unknown. OBJECTIVE The study aims to evaluate the incidence and pattern of EPBD in children with congenital hypopituitarism and to evaluate whether it can serve as a clue to diagnose this condition. PATIENTS AND METHODS Retrospective analysis of hospital record of patients of short stature ...